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CAD5 cinnamyl alcohol dehydrogenase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829572, updated on 19-Feb-2025
Official Symbol
CAD5
Official Full Name
cinnamyl alcohol dehydrogenase 5
Primary source
TAIR:AT4G34230
Locus tag
AT4G34230
See related
Araport:AT4G34230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCAD5; CAD-5; cinnamyl alcohol dehydrogenase 5; F10M10.11
Summary
Encodes a catalytically active cinnamyl alcohol dehydrogenase which uses p-coumaryl aldehyde as a preferred substrate. It can also use sinapyl, caffeyl, coniferyl and d-hydroxyconiferyl aldehydes as substrates.
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See CAD5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Sequence:
Chromosome: 4; NC_003075.7 (16386631..16388940, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene aldehyde dehydrogenase 3I1 Neighboring gene 3-ketoacyl-CoA synthase 16

Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure. Anderson NA, et al. Plant Cell, 2015 Aug. PMID 26265762, Free PMC Article
  2. Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana. Chen AP, et al. J Plant Res, 2007 Mar. PMID 17287892
  3. Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4. Youn B, et al. Org Biomol Chem, 2006 May 7. PMID 16633561
  4. CINNAMYL ALCOHOL DEHYDROGENASE-C and -D are the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis. Sibout R, et al. Plant Cell, 2005 Jul. PMID 15937231, Free PMC Article
  5. Expression pattern of two paralogs encoding cinnamyl alcohol dehydrogenases in Arabidopsis. Isolation and characterization of the corresponding mutants. Sibout R, et al. Plant Physiol, 2003 Jun. PMID 12805615, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
    Title: Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.
  2. Repressing both the CAD and the CCR activities results in sterility and dwarfism.
    Title: The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
  3. These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana.
    Title: Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana.
  4. determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
    Title: Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_001036711.1
NM_119587.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cinnamyl-alcohol dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cinnamyl-alcohol dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lignin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lignin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lignin biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
Preferred Names
cinnamyl alcohol dehydrogenase 5
NP_001031788.1
  • cinnamyl alcohol dehydrogenase 5 (CAD5); CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: GroES-like zinc-binding alcohol dehydrogenase family protein (TAIR:AT3G19450.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_195149.1
  • cinnamyl alcohol dehydrogenase 5 (CAD5); CONTAINS InterPro DOMAIN/s: GroES-like (InterPro:IPR011032), Polyketide synthase, enoylreductase (InterPro:IPR020843), Alcohol dehydrogenase GroES-like (InterPro:IPR013154), Alcohol dehydrogenase, zinc-containing, conserved site (InterPro:IPR002328), Alcohol dehydrogenase, C-terminal (InterPro:IPR013149), Alcohol dehydrogenase superfamily, zinc-containing (InterPro:IPR002085); BEST Arabidopsis thaliana protein match is: GroES-like zinc-binding alcohol dehydrogenase family protein (TAIR:AT3G19450.1); Has 41203 Blast hits to 41171 proteins in 3032 species: Archae - 764; Bacteria - 27799; Metazoa - 1384; Fungi - 3121; Plants - 2810; Viruses - 3; Other Eukaryotes - 5322 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16386631..16388940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119587.4 → NP_195149.1  cinnamyl alcohol dehydrogenase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195149.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49482, Q53ZN0
    UniProtKB/TrEMBL
    A0A178V3B0, A0A5S9XYH8
    Conserved Domains (1) summary
    PLN02514
    Location:1 → 357
    PLN02514; cinnamyl-alcohol dehydrogenase

  2. NM_001036711.1 → NP_001031788.1  cinnamyl alcohol dehydrogenase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JKM2
    Conserved Domains (2) summary
    PLN02514
    Location:1 → 357
    PLN02514; cinnamyl-alcohol dehydrogenase
    cd05283
    Location:11 → 349
    CAD1; Cinnamyl alcohol dehydrogenases (CAD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O49482.1

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