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TRRAP transformation/transcription domain associated protein [ Homo sapiens (human) ]

Gene ID: 8295, updated on 4-Nov-2018

Summary

Official Symbol
TRRAPprovided by HGNC
Official Full Name
transformation/transcription domain associated proteinprovided by HGNC
Primary source
HGNC:HGNC:12347
See related
Ensembl:ENSG00000196367 MIM:603015; Vega:OTTHUMG00000150403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tra1; TR-AP; PAF400; STAF40; PAF350/400
Summary
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in testis (RPKM 10.2), ovary (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See TRRAP in Genome Data Viewer
Location:
7q22.1
Exon count:
72
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (98878490..99013243)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (98476113..98610866)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 393, pseudogene Neighboring gene transmembrane protein 130 Neighboring gene small Cajal body-specific RNA 28 Neighboring gene microRNA 3609 Neighboring gene ring finger protein 14 pseudogene Neighboring gene uncharacterized LOC101927550 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene karyopherin subunit alpha 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat SKIP recruits c-Myc and TRRAP to the HIV-1 Tat-activated LTR promoter. The c-Myc:TRRAP complex is repressive to HIV-1 transcription under UV stress PubMed
tat The core of the p400/TRRAP complex, consists of BAF53A, P400, RUVBL1, RUVBL2, TRRAP, are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10671

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
PCAF complex NAS
Non-traceable Author Statement
more info
PubMed 
SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
Swr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transformation/transcription domain-associated protein
Names
350/400 kDa PCAF-associated factor
tra1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030010.1 RefSeqGene

    Range
    5001..139754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244580.1NP_001231509.1  transformation/transcription domain-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001231509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AC004893, AC004991, AF076974, AF110377, BQ006165
    Consensus CDS
    CCDS59066.1
    UniProtKB/Swiss-Prot
    Q9Y4A5
    Related
    ENSP00000352925.4, OTTHUMP00000197292, ENST00000359863.8, OTTHUMT00000317978
    Conserved Domains (3) summary
    cd05163
    Location:34963783
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28513204
    FAT; FAT domain
    pfam02260
    Location:38323859
    FATC; FATC domain
  2. NM_003496.3NP_003487.1  transformation/transcription domain-associated protein isoform 2

    See identical proteins and their annotated locations for NP_003487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004991, AF076974, AF110377, BQ006165
    Consensus CDS
    CCDS5659.1
    UniProtKB/Swiss-Prot
    Q9Y4A5
    Related
    ENSP00000347733.3, OTTHUMP00000197293, ENST00000355540.7, OTTHUMT00000317979
    Conserved Domains (3) summary
    cd05163
    Location:34673754
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28333175
    FAT; FAT domain
    pfam02260
    Location:38033830
    FATC; FATC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    98878490..99013243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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