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HDA14 histone deacetylase 14 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829484, updated on 19-Feb-2025
Official Symbol
HDA14
Official Full Name
histone deacetylase 14
Primary source
TAIR:AT4G33470
Locus tag
AT4G33470
See related
Araport:AT4G33470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHDA14; F17M5.230; F17M5_230; histone deacetylase 14
Summary
Encodes HDA14, a member of the histone deacetylase family proteins that can deacetylate a-tubulin, associates with a/b-tubulin and is retained on GTP/taxol-stabilized microtubules, at least in part, by direct association with the PP2A-A2 subunit. The association of a histone deacetylase with PP2A suggests a direct link between protein phosphorylation and acetylation.
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See HDA14 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (16102595..16105550, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ABC transporter family protein Neighboring gene SCR-like 22 Neighboring gene uncharacterized protein Neighboring gene BTB/POZ domain protein TNFAIP protein Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase family protein

Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rice histone deacetylase 10 and Arabidopsis histone deacetylase 14 genes encode N-acetylserotonin deacetylase, which catalyzes conversion of N-acetylserotonin into serotonin, a reverse reaction for melatonin biosynthesis in plants. Lee K, et al. J Pineal Res, 2018 Mar. PMID 29247559
  2. Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis. Hartl M, et al. Mol Syst Biol, 2017 Oct 23. PMID 29061669, Free PMC Article
  3. Subcellular localization of class II HDAs in Arabidopsis thaliana: nucleocytoplasmic shuttling of HDA15 is driven by light. Alinsug MV, et al. PLoS One, 2012. PMID 22363501, Free PMC Article
  4. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3. Tran HT, et al. Plant J, 2012 Jul. PMID 22404109
  5. Structure of Arabidopsis HISTONE DEACETYLASE15. Chen CY, et al. Plant Physiol, 2020 Nov. PMID 32878973, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HDA14, ELP3 and the PP2A A-subunits A1, A2 and A3 all reside in both the nucleus and cytosol of the cell.
    Title: Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description
NM_119501.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in melatonin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of photosynthesis, light reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tubulin deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
Preferred Names
histone deacetylase 14
NP_567921.1
  • histone deacetylase 14 (hda14); FUNCTIONS IN: histone deacetylase activity; INVOLVED IN: histone deacetylation; LOCATED IN: chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone deacetylase superfamily (InterPro:IPR000286); BEST Arabidopsis thaliana protein match is: histone deacetylase 5 (TAIR:AT5G61060.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16102595..16105550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119501.4 → NP_567921.1  histone deacetylase 14 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567921.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q941D6, Q9SZC4
    UniProtKB/TrEMBL
    A0A178V1U6, A0A5S9XYY9
    Conserved Domains (1) summary
    cd09992
    Location:80 → 387
    HDAC_classII; Histone deacetylases and histone-like deacetylases, classII
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q941D6.1

Gene LinkOut

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