ISU1 SufE/NifU family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: ISU1
Gene description: SufE/NifU family protein
Primary source: Araport:AT4G22220
Locus tag: AT4G22220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATISU1; T10I14.50; T10I14_50
Summary: Encodes a mitochondrial protein similar to E.coli IscU. In bacteria, IscU is a scaffold protein accepting sulfur and iron to build a transient Fe-S cluster,which is subsequently transferred to a target apoprotein.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Results suggest that AtHscA2 in cooperation with AtIsu1 and AtHscB play an important role in the regulation of the Fe-S cluster assembly pathway in plant mitochondria.
Title: The mitochondrial proteins AtHscB and AtIsu1 involved in Fe-S cluster assembly interact with the Hsp70-type chaperon AtHscA2 and modulate its catalytic activity.
ISU1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
Title: Functional analysis of Arabidopsis genes involved in mitochondrial iron-sulfur cluster assembly.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_118347.3

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron-sulfur cluster assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
NOT located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

NP_193953.1

ISU1; CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, N-terminal (InterPro:IPR002871), ISC system FeS cluster assembly, IscU scaffold (InterPro:IPR011339); BEST Arabidopsis thaliana protein match is: ISCU-like 3 (TAIR:AT4G04080.1); Has 5453 Blast hits to 5453 proteins in 1998 species: Archae - 110; Bacteria - 3654; Metazoa - 148; Fungi - 154; Plants - 89; Viruses - 0; Other Eukaryotes - 1298 (source: NCBI BLink).