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SLC10A3 solute carrier family 10 member 3 [ Homo sapiens (human) ]

Gene ID: 8273, updated on 1-Aug-2020

Summary

Official Symbol
SLC10A3provided by HGNC
Official Full Name
solute carrier family 10 member 3provided by HGNC
Primary source
HGNC:HGNC:22979
See related
Ensembl:ENSG00000126903 MIM:312090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P3; DXS253E
Summary
This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in placenta (RPKM 8.9), ovary (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See SLC10A3 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154487310..154490656, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153715645..153719002, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene plexin A3 Neighboring gene L antigen family member 3 Neighboring gene ubiquitin like 4A Neighboring gene RNA, 7SL, cytoplasmic 697, pseudogene Neighboring gene FAM3 metabolism regulating signaling molecule A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bile acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
P3 protein
Names
Protein P3
solute carrier family 10 (sodium/bile acid cotransporter family), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013261.2 RefSeqGene

    Range
    5024..8342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142391.3NP_001135863.1  P3 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001135863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and is alternatively spliced in the 5' coding region compared to variant 1. The resulting isoform (2) is shorter missing an in-frame protein segment of 29 amino acids compared to isoform 1.
    Source sequence(s)
    BC004966, BM981524, HY035183
    Consensus CDS
    CCDS48195.1
    UniProtKB/Swiss-Prot
    P09131
    Related
    ENSP00000358663.4, ENST00000369649.8
    Conserved Domains (1) summary
    TIGR00841
    Location:172445
    bass; bile acid transporter
  2. NM_001142392.3NP_001135864.1  P3 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001135864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC004966, BM981524, BP281642, BX401493, HY035183
    Consensus CDS
    CCDS14755.1
    UniProtKB/Swiss-Prot
    P09131
    Related
    ENSP00000377212.4, ENST00000393587.4
    Conserved Domains (1) summary
    TIGR00841
    Location:201474
    bass; bile acid transporter
  3. NM_019848.5NP_062822.1  P3 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_062822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    BC004966, BG327309, BM981524, BX401493
    Consensus CDS
    CCDS14755.1
    UniProtKB/Swiss-Prot
    P09131
    Related
    ENSP00000499188.1, ENST00000651600.1
    Conserved Domains (1) summary
    TIGR00841
    Location:201474
    bass; bile acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154487310..154490656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531201.2XP_011529503.1  P3 protein isoform X5

    See identical proteins and their annotated locations for XP_011529503.1

    UniProtKB/Swiss-Prot
    P09131
    Conserved Domains (1) summary
    TIGR00841
    Location:201474
    bass; bile acid transporter
  2. XM_006724848.3XP_006724911.1  P3 protein isoform X2

    Conserved Domains (1) summary
    TIGR00841
    Location:265538
    bass; bile acid transporter
  3. XM_006724847.3XP_006724910.1  P3 protein isoform X1

    Conserved Domains (1) summary
    TIGR00841
    Location:294567
    bass; bile acid transporter
  4. XM_011531200.3XP_011529502.2  P3 protein isoform X3

    UniProtKB/TrEMBL
    A0A0A0MS43
    Related
    ENSP00000377211.1, ENST00000393586.1
    Conserved Domains (1) summary
    TIGR00841
    Location:256529
    bass; bile acid transporter
  5. XM_005277913.5XP_005277970.1  P3 protein isoform X4

    UniProtKB/TrEMBL
    A0A0A0MS43
    Conserved Domains (1) summary
    TIGR00841
    Location:256529
    bass; bile acid transporter
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