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TMEM187 transmembrane protein 187 [ Homo sapiens (human) ]

Gene ID: 8269, updated on 23-Nov-2021

Summary

Official Symbol
TMEM187provided by HGNC
Official Full Name
transmembrane protein 187provided by HGNC
Primary source
HGNC:HGNC:13705
See related
Ensembl:ENSG00000177854 MIM:300059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITBA1; CXorf12; DXS9878E
Summary
This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in prostate (RPKM 3.1), fat (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM187 in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153972754..153983194)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153238205..153248645)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene renin binding protein Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2 Neighboring gene CRISPRi-validated cis-regulatory element chrX.2695 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ95849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in transport vesicle IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021222.1 RefSeqGene

    Range
    5215..15655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003492.3NP_003483.1  transmembrane protein 187

    See identical proteins and their annotated locations for NP_003483.1

    Status: REVIEWED

    Source sequence(s)
    BC008203, U52112
    Consensus CDS
    CCDS14739.1
    UniProtKB/Swiss-Prot
    Q14656
    Related
    ENSP00000358999.4, ENST00000369982.5
    Conserved Domains (1) summary
    pfam15100
    Location:8245
    TMEM187; TMEM187 protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153972754..153983194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531199.2XP_011529501.1  transmembrane protein 187 isoform X1

    See identical proteins and their annotated locations for XP_011529501.1

    UniProtKB/Swiss-Prot
    Q14656
    Conserved Domains (1) summary
    pfam15100
    Location:8245
    TMEM187; TMEM187 protein family
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