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GRF1 general regulatory factor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826479, updated on 7-Sep-2023

Summary

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Gene symbol
GRF1
Gene description
general regulatory factor 1
Primary source
Araport:AT4G09000
Locus tag
AT4G09000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
general regulatory factor 1; GENERAL REGULATORY FACTOR1-G-BOX FACTOR 14-3-3 HOMOLOG ISOFORM CHI; GF14 CHI
Summary
Encodes a 14-3-3 gene, designated GRF1 chi (for general regulatory factor1-G-box factor 14-3-3 homolog isoform chi). The major native forms of 14-3-3s are homo- and hetero-dimers, the biological functions of which are to interact physically with specific client proteins and thereby effect a change in the client. As a result, 14-3-3s are involved in a vast array of processes such as the response to stress, cell-cycle control, and apoptosis, serving as adapters, activators, and repressors. There are currently 133 full-length sequences available.
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Genomic context

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Location:
chromosome: 4
Exon count:
5
Sequence:
Chromosome: 4; NC_003075.7 (5775210..5777481)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene DNA (cytosine-5-)-methyltransferase family protein Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ascorbate peroxidase 4 Neighboring gene ncRNA Neighboring gene Mitochondrial ribosomal protein L27

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism. Piya S, et al. J Exp Bot, 2020 Feb 19. PMID 31701146, Free PMC Article
  2. Identification of 14-3-3 proteins as a target of ATL31 ubiquitin ligase, a regulator of the C/N response in Arabidopsis. Sato T, et al. Plant J, 2011 Oct. PMID 21668537
  3. Phosphorylation of Arabidopsis ubiquitin ligase ATL31 is critical for plant carbon/nitrogen nutrient balance response and controls the stability of 14-3-3 proteins. Yasuda S, et al. J Biol Chem, 2014 May 30. PMID 24722992, Free PMC Article
  4. TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins. Latz A, et al. Plant J, 2007 Nov. PMID 17764516
  5. Complex feedback regulations govern the expression of miRNA396 and its GRF target genes. Hewezi T, et al. Plant Signal Behav, 2012 Jul. PMID 22751317, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.
    Title: A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.
  2. cuc1 grf1/2/3, cuc2 grf1/2/3, and cuc3 grf1/2/3 quadruple mutants showed dramatic increases in cotyledon fusion as well as floral organ fusion.
    Title: Genetic interaction between GROWTH-REGULATING FACTOR and CUP-SHAPED COTYLEDON in organ separation.
  3. In vitro assays showed that ubiquitination of 14-3-3chi is catalyzed by ATL31. Degradation of 14-3-3chiin vivo was shown to be correlated with ATL31 activity, and to occur in a proteasome-dependent manner.
    Title: Identification of 14-3-3 proteins as a target of ATL31 ubiquitin ligase, a regulator of the C/N response in Arabidopsis.
  4. Homeostasis between miR396 and the target genes GRF1 and GRF3 is established through reciprocal feedback regulation.
    Title: Complex feedback regulations govern the expression of miRNA396 and its GRF target genes.
  5. Work elucidates how 14-3-3s function as modulators of plant N and S metabolic pathways.
    Title: 14-3-3 proteins fine-tune plant nutrient metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001160744.1
NM_116969.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphorylated amino acid binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
general regulatory factor 1
NP_001154216.1
  • general regulatory factor 1 (GRF1); CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: GF14 protein phi chain (TAIR:AT1G35160.2); Has 2700 Blast hits to 2690 proteins in 380 species: Archae - 0; Bacteria - 6; Metazoa - 1254; Fungi - 308; Plants - 767; Viruses - 0; Other Eukaryotes - 365 (source: NCBI BLink).
NP_567344.1
  • general regulatory factor 1 (GRF1); FUNCTIONS IN: protein phosphorylated amino acid binding; INVOLVED IN: response to cadmium ion; LOCATED IN: in 7 components; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: GF14 protein phi chain (TAIR:AT1G35160.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    5775210..5777481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160744.1 → NP_001154216.1  general regulatory factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UZ53, F4JJ94
    Conserved Domains (1) summary
    cd10026
    Location:10 → 244
    14-3-3_plant; Plant 14-3-3 protein domain

  2. NM_116969.3 → NP_567344.1  general regulatory factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567344.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42643, Q945M2, Q9M0S7
    UniProtKB/TrEMBL
    A0A178UZ53, A0A5S9XQK2
    Conserved Domains (1) summary
    cl02098
    Location:10 → 246
    14-3-3; 14-3-3 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42643.3

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