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NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [ Homo sapiens (human) ]

Gene ID: 8260, updated on 17-Jun-2019

Summary

Official Symbol
NAA10provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:18704
See related
Ensembl:ENSG00000102030 MIM:300013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1
Summary
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in fat (RPKM 16.8), appendix (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See NAA10 in Genome Data Viewer
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153929225..153935037, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153195280..153200607, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 2 Neighboring gene Rho GTPase activating protein 4 Neighboring gene renin binding protein Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ78896, MGC71248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide-glutamate-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide-serine-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA packaging TAS
Traceable Author Statement
more info
PubMed 
N-terminal peptidyl-glutamic acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal peptidyl-serine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
PubMed 
internal protein amino acid acetylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric IDA
Inferred from Direct Assay
more info
PubMed 
protein acetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NatA complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 10
Names
ARD1 homolog A, N-acetyltransferase
N-acetyltransferase ARD1, human homolog of
N-terminal acetyltransferase complex ARD1 subunit homolog A
natA catalytic subunit Naa10
NP_001243048.1
NP_001243049.1
NP_003482.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031987.1 RefSeqGene

    Range
    5001..10328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256119.2NP_001243048.1  N-alpha-acetyltransferase 10 isoform 2

    See identical proteins and their annotated locations for NP_001243048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AY183135, CA313208, CR979270, U52112
    Consensus CDS
    CCDS59179.1
    UniProtKB/Swiss-Prot
    P41227
    Related
    ENSP00000359026.1, ENST00000370009.5
    Conserved Domains (1) summary
    COG0456
    Location:1134
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
  2. NM_001256120.2NP_001243049.1  N-alpha-acetyltransferase 10 isoform 3

    See identical proteins and their annotated locations for NP_001243049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AK315997, AY183135, BI192945, CA313208, CR979270, U52112
    UniProtKB/TrEMBL
    B7Z9N2
    Conserved Domains (1) summary
    COG0456
    Location:1143
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
  3. NM_003491.4NP_003482.1  N-alpha-acetyltransferase 10 isoform 1

    See identical proteins and their annotated locations for NP_003482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC000308, CA313208, CR979270, U52112
    Consensus CDS
    CCDS14737.1
    UniProtKB/Swiss-Prot
    P41227
    Related
    ENSP00000417763.1, ENST00000464845.6
    Conserved Domains (1) summary
    COG0456
    Location:1149
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153929225..153935037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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