U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACS1 ACC synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825324, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Gene symbol
ACS1
Gene description
ACC synthase 1
Primary source
Araport:AT3G61510
Locus tag
AT3G61510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; ACC synthase 1; ARABIDOPSIS THALIANA 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; AT-ACS1
Summary
Encodes a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family. The gene is transcriptionally active but enzymatically inactive. The predicted amino-acid sequence of ACS1 is missing the highly conserved tripeptide, Thr-Asn-Pro (TNP), between Ile204 and Ser205. Introduction of TNP into ACS1 restores the ACS activity.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (22763495..22766010, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene BPS1-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phosphoenolpyruvate carboxylase family protein Neighboring gene alpha/beta-Hydrolases superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis. Lv SF, et al. Plant Biol (Stuttg), 2019 Jul. PMID 30734982
  2. Characterization of two members (ACS1 and ACS3) of the 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana. Liang X, et al. Gene, 1995 Dec 29. PMID 8566772
  3. Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family. Tsuchisaka A, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983000, Free PMC Article
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activity corresponds to the onset of leaf senescence
    Title: The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_116016.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in ethylene biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ACC synthase 1
NP_191710.1
  • ACC synthase 1 (ACS1); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-amino-cyclopropane-1-carboxylate synthase 2 (TAIR:AT1G01480.1); Has 22999 Blast hits to 22998 proteins in 2818 species: Archae - 808; Bacteria - 15898; Metazoa - 560; Fungi - 631; Plants - 1241; Viruses - 0; Other Eukaryotes - 3861 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22763495..22766010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116016.2 → NP_191710.1  ACC synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06429, Q43368, Q9S9C6
    UniProtKB/TrEMBL
    A0A654FJS5
    Conserved Domains (3) summary
    cd00609
    Location:89 → 427
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02994
    Location:3 → 154
    PLN02994; 1-aminocyclopropane-1-carboxylate synthase
    PLN02376
    Location:4 → 488
    PLN02376; 1-aminocyclopropane-1-carboxylate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2204225A.1
Q06429.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools