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CDC2 cell division control 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824036, updated on 22-Aug-2021

Summary

Gene symbol
CDC2
Gene description
cell division control 2
Primary source
Araport:AT3G48750
Locus tag
AT3G48750
Gene type
protein coding
RNA name
cell division control 2
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CDC2A; CDC2AAT; CDK2; CDKA1; CDKA;1; cell division control 2; CYCLIN-DEPENDENT KINASE A;1; P34CDC2
Summary
A-type cyclin-dependent kinase. Together with its specific inhibitor, the Kip-related protein, KRP2 they regulate the mitosis-to-endocycle transition during leaf development. Dominant negative mutations abolish cell division. Loss of function phenotype has reduced fertility with failure to transmit via pollen. Pollen development is arrested at the second mitotic division. Expression is regulated by environmental and chemical signals. Part of the promoter is responsible for expression in trichomes. Functions as a positive regulator of cell proliferation during development of the male gametophyte, embryo and endosperm. Phosphorylation of threonine 161 is required for activation of its associated kinase.
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Genomic context

See CDC2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (18071454..18074641)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nodulin MtN3 family protein Neighboring gene tRNA Neighboring gene DHHC-type zinc finger family protein Neighboring gene ATP/DNA binding protein Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CDC2 gene: The CDC2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
  • Orthologs
NM_114734.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within asymmetric cell division IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cytokinesis by cell plate formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gametophyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in guard mother cell cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in guard mother cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pollen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in symmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cortical microtubule, transverse to long axis IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
 
located_in preprophase band TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cell division control 2
NP_566911.1
  • cell division control 2 (CDC2); FUNCTIONS IN: protein binding, protein kinase activity, cyclin-dependent protein kinase activity, kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase B1;2 (TAIR:AT2G38620.2); Has 126125 Blast hits to 124135 proteins in 4221 species: Archae - 112; Bacteria - 14002; Metazoa - 46757; Fungi - 13170; Plants - 30525; Viruses - 484; Other Eukaryotes - 21075 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    18071454..18074641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114734.4NP_566911.1  cell division control 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566911.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24100
    UniProtKB/TrEMBL
    A0A178VG41
    Conserved Domains (1) summary
    PLN00009
    Location:1294
    PLN00009; cyclin-dependent kinase A; Provisional
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