CSR1 chlorsulfuron/imidazolinone resistant 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CSR1
Official Full Name: chlorsulfuron/imidazolinone resistant 1
Primary source: TAIR:AT3G48560
Locus tag: AT3G48560
See related: Araport:AT3G48560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACETOHYDROXY ACID SYNTHASE; ACETOLACTATE SYNTHASE; AHAS; ALS; chlorsulfuron/imidazolinone resistant 1; IMIDAZOLE RESISTANT 1; IMR1; TRIAZOLOPYRIMIDINE RESISTANT 5; TZP5
Summary: Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_114714.3

Function	Evidence Code	Pubs
enables acetolactate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetolactate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetolactate synthase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-valine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-valine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IEA Inferred from Electronic Annotation more info
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed

NP_190425.1

chlorsulfuron/imidazolinone resistant 1 (CSR1); FUNCTIONS IN: acetolactate synthase activity, pyruvate decarboxylase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TPP-binding enzyme, conserved site (InterPro:IPR000399), Thiamine pyrophosphate enzyme, central domain (InterPro:IPR012000), Acetolactate synthase, large subunit, biosynthetic (InterPro:IPR012846), Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (InterPro:IPR012001), Thiamine pyrophosphate enzyme, C-terminal TPP-binding (InterPro:IPR011766); BEST Arabidopsis thaliana protein match is: Thiamine pyrophosphate dependent pyruvate decarboxylase family protein (TAIR:AT5G17380.1); Has 30963 Blast hits to 30605 proteins in 2694 species: Archae - 488; Bacteria - 17421; Metazoa - 266; Fungi - 871; Plants - 599; Viruses - 25; Other Eukaryotes - 11293 (source: NCBI BLink).