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CAPN2 calpain 2 [ Homo sapiens (human) ]

Gene ID: 824, updated on 8-Aug-2021

Summary

Official Symbol
CAPN2provided by HGNC
Official Full Name
calpain 2provided by HGNC
Primary source
HGNC:HGNC:1479
See related
Ensembl:ENSG00000162909 MIM:114230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CANP2; mCANP; CANPL2; CANPml
Summary
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in lung (RPKM 90.0), gall bladder (RPKM 66.0) and 25 other tissues See more
Orthologs
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Genomic context

See CAPN2 in Genome Data Viewer
Location:
1q41
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (223701597..223776018)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223889299..223963720)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene SNRPE pseudogene 10 Neighboring gene uncharacterized LOC105373281 Neighboring gene RNA, U6 small nuclear 1248, pseudogene Neighboring gene uncharacterized LOC105373046 Neighboring gene uncharacterized LOC105373041 Neighboring gene tumor protein p53 binding protein 2 Neighboring gene prohibitin pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants associated with general and MMR vaccine-related febrile seizures.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Activation of the Ca(2+)-dependent protease, calpain, is involved in cytotoxic effects mediated by HIV-1 gp120 in neuroblastoma cultures PubMed
Tat tat HIV-1 Tat increases plasma membrane (PM) dopamine transporter (DAT) activity and calpain protease activity at the PM PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables cytoskeletal protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis involved in cellular protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in cortical actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calpain-2 catalytic subunit
Names
CANP 2
M-calpain
calcium-activated neutral proteinase 2
calpain 2, (m/II) large subunit
calpain 2, large [catalytic] subunit
calpain 2, large subunit
calpain M-type
calpain, large polypeptide L2
millimolar-calpain
NP_001139540.1
NP_001739.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146068.2NP_001139540.1  calpain-2 catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001139540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC096542, AC099065
    Consensus CDS
    CCDS53478.1
    UniProtKB/Swiss-Prot
    P17655
    UniProtKB/TrEMBL
    B4DN77, Q59EF6
    Related
    ENSP00000413158.2, ENST00000433674.6
    Conserved Domains (3) summary
    pfam00648
    Location:2264
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:285429
    Calpain_III; Calpain large subunit, domain III
    cd16199
    Location:455622
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
  2. NM_001748.5NP_001739.3  calpain-2 catalytic subunit isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC096542, AC099065
    Consensus CDS
    CCDS31035.1
    Related
    ENSP00000295006.5, ENST00000295006.6
    Conserved Domains (3) summary
    pfam00648
    Location:46342
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:363507
    Calpain_III; Calpain large subunit, domain III
    cd16199
    Location:533700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    223701597..223776018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957688.1 RNA Sequence

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