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USP11 ubiquitin specific peptidase 11 [ Homo sapiens (human) ]

Gene ID: 8237, updated on 1-Jun-2020

Summary

Official Symbol
USP11provided by HGNC
Official Full Name
ubiquitin specific peptidase 11provided by HGNC
Primary source
HGNC:HGNC:12609
See related
Ensembl:ENSG00000102226 MIM:300050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UHX1
Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues See more
Orthologs

Genomic context

See USP11 in Genome Data Viewer
Location:
Xp11.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47233009..47248328)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47092089..47107727)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ubiquitin like modifier activating enzyme 1 Neighboring gene uncharacterized LOC105373194 Neighboring gene inactivation escape 1 Neighboring gene cyclin dependent kinase 16 Neighboring gene nicolin 2, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 785, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with ubiquitin specific peptidase 11 (USP11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 11
Names
deubiquitinating enzyme 11
ubiquitin carboxyl-terminal hydrolase, X-linked
ubiquitin thioesterase 11
ubiquitin thiolesterase 11
ubiquitin-specific processing protease 11
NP_001358001.1
XP_005272731.1
XP_011542290.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012546.1 RefSeqGene

    Range
    5095..20414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001371072.1NP_001358001.1  ubiquitin carboxyl-terminal hydrolase 11

    Status: VALIDATED

    Source sequence(s)
    AB073597, BC140849
    Consensus CDS
    CCDS14277.1
    Related
    ENSP00000366311.2, ENST00000377107.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47233009..47248328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272674.4XP_005272731.1  ubiquitin carboxyl-terminal hydrolase 11 isoform X1

    See identical proteins and their annotated locations for XP_005272731.1

    UniProtKB/Swiss-Prot
    P51784
    UniProtKB/TrEMBL
    B4DGK3
    Conserved Domains (3) summary
    cd02674
    Location:504655
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:37216
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:207320
    USP7_C2; Ubiquitin-specific protease C-terminal
  2. XM_011543988.1XP_011542290.1  ubiquitin carboxyl-terminal hydrolase 11 isoform X1

    See identical proteins and their annotated locations for XP_011542290.1

    UniProtKB/Swiss-Prot
    P51784
    UniProtKB/TrEMBL
    B4DGK3
    Conserved Domains (3) summary
    cd02674
    Location:504655
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:37216
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:207320
    USP7_C2; Ubiquitin-specific protease C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004651.3: Suppressed sequence

    Description
    NM_004651.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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