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ZRSR2 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 [ Homo sapiens (human) ]

Gene ID: 8233, updated on 7-Jun-2020

Summary

Official Symbol
ZRSR2provided by HGNC
Official Full Name
zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2provided by HGNC
Primary source
HGNC:HGNC:23019
See related
Ensembl:ENSG00000169249 MIM:300028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2
Summary
This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 3.8), spleen (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See ZRSR2 in Genome Data Viewer
Location:
Xp22.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (15790472..15826807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15808574..15841383)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene collectrin, amino acid transport regulator Neighboring gene CA5BP1-CA5B readthrough Neighboring gene carbonic anhydrase 5B pseudogene 1 Neighboring gene carbonic anhydrase 5B Neighboring gene inactivation escape 2 Neighboring gene adaptor related protein complex 1 subunit sigma 2 Neighboring gene RNA, U5F small nuclear 7, pseudogene Neighboring gene SET pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142014, MGC142040

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
pre-mRNA 3'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA 3'-splice site binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
spliceosomal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
U2AF IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
Names
U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2
U2(RNU2) small nuclear RNA auxiliary factor 1-like 2
U2AF35-related protein
renal carcinoma antigen NY-REN-20
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012746.1 RefSeqGene

    Range
    5001..37810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_618

mRNA and Protein(s)

  1. NM_005089.4NP_005080.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

    See identical proteins and their annotated locations for NP_005080.1

    Status: REVIEWED

    Source sequence(s)
    BC113480
    Consensus CDS
    CCDS14172.1
    UniProtKB/Swiss-Prot
    Q15696
    Related
    ENSP00000303015.7, ENST00000307771.7
    Conserved Domains (2) summary
    cd12540
    Location:199303
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:167191
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    15790472..15826807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274597.3XP_005274654.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X3

    Conserved Domains (2) summary
    cd12540
    Location:61165
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:2953
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  2. XM_017029881.2XP_016885370.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X1

  3. XM_024452455.1XP_024308223.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X3

    Conserved Domains (2) summary
    cd12540
    Location:61165
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:2953
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  4. XM_024452456.1XP_024308224.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X3

    Conserved Domains (2) summary
    cd12540
    Location:61165
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:2953
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  5. XM_017029883.2XP_016885372.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X3

    Conserved Domains (2) summary
    cd12540
    Location:61165
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:2953
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  6. XM_011545589.3XP_011543891.2  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X2

  7. XM_017029882.2XP_016885371.1  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 isoform X3

    Conserved Domains (2) summary
    cd12540
    Location:61165
    RRM_U2AFBPL; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (U2AFBPL) and similar proteins
    pfam00642
    Location:2953
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
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