Format

Send to:

Choose Destination

AKAP17A A-kinase anchoring protein 17A [ Homo sapiens (human) ]

Gene ID: 8227, updated on 5-Aug-2018

Summary

Official Symbol
AKAP17Aprovided by HGNC
Official Full Name
A-kinase anchoring protein 17Aprovided by HGNC
Primary source
HGNC:HGNC:18783
See related
Ensembl:ENSG00000197976 MIM:312095; MIM:465000; Vega:OTTHUMG00000021063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E
Summary
This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in spleen (RPKM 26.3), bone marrow (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See AKAP17A in Genome Data Viewer
Location:
Xp22.33 and Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (1591593..1602520)
109 current GRCh38.p12 (GCF_000001405.38) Y NC_000024.10 (1591593..1602520)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1710486..1721413)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1660486..1671413)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC107985706 Neighboring gene uncharacterized LOC107985637

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene uncharacterized LOC107985706 Neighboring gene uncharacterized LOC107985637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ98315, MGC39904, MGC125365, MGC125366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell activation NAS
Non-traceable Author Statement
more info
PubMed 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A-kinase anchor protein 17A
Names
A kinase (PRKA) anchor protein 17A
B-lymphocyte surface antigen
protein kinase A-anchoring protein 17A
pseudoautosomal gene XE7
splicing factor, arginine/serine-rich 17A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021470.1 RefSeqGene

    Range
    5001..15928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005088.2NP_005079.2  A-kinase anchor protein 17A isoform 1

    See identical proteins and their annotated locations for NP_005079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC015800, BC016935, BC028151, BM046630, BM713425, M99578
    Consensus CDS
    CCDS14116.1
    UniProtKB/Swiss-Prot
    Q02040
    UniProtKB/TrEMBL
    Q05DA9
    Related
    ENSP00000324827.3, OTTHUMP00000022833, ENST00000313871.8, OTTHUMT00000055609
    Conserved Domains (3) summary
    cd12264
    Location:143265
    RRM_AKAP17A; RNA recognition motif found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins
    cd16269
    Location:424433
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:345433
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_027383.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate coding exon that results in a frameshift and prematurely truncated open reading frame. The transcript is predicted to be subject to nonsense-mediated decay (NMD) and thus the predicted protein product is not annotated on the record.
    Source sequence(s)
    BC015800, BC016935, BC028151, BC110497, L03426, M99578
    Related
    ENST00000474361.6, OTTHUMT00000055607

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    1591593..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p12 Primary Assembly

    Range
    1591593..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center