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AKAP17A A-kinase anchoring protein 17A [ Homo sapiens (human) ]

Gene ID: 8227, updated on 4-Dec-2022

Summary

Official Symbol
AKAP17Aprovided by HGNC
Official Full Name
A-kinase anchoring protein 17Aprovided by HGNC
Primary source
HGNC:HGNC:18783
See related
Ensembl:ENSG00000197976 MIM:312095; MIM:465000; AllianceGenome:HGNC:18783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E
Summary
This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in spleen (RPKM 26.3), bone marrow (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

See AKAP17A in Genome Data Viewer
Location:
X;Y
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1591604..1602520)
110 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1591604..1602520)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1393022..1403889)
110 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1455997..1466654)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1710497..1721413)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1660497..1671413)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene long intergenic non-protein coding RNA 2968 Neighboring gene uncharacterized LOC105379413

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene ASMTL antisense RNA 1 Neighboring gene acetylserotonin O-methyltransferase like Neighboring gene P2Y receptor family member 8 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene long intergenic non-protein coding RNA 2968 Neighboring gene uncharacterized LOC105379413

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ98315, MGC39904, MGC125365, MGC125366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase A binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A-kinase anchor protein 17A
Names
A kinase (PRKA) anchor protein 17A
B-lymphocyte surface antigen
protein kinase A-anchoring protein 17A
pseudoautosomal gene XE7
splicing factor, arginine/serine-rich 17A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021470.1 RefSeqGene

    Range
    5012..15928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005088.3NP_005079.2  A-kinase anchor protein 17A isoform 1

    See identical proteins and their annotated locations for NP_005079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC015800, BC016935, BC028151, BM046630, BM713425, M99578
    Consensus CDS
    CCDS14116.1
    UniProtKB/Swiss-Prot
    Q02040, Q8N6U9
    UniProtKB/TrEMBL
    Q05DA9
    Related
    ENSP00000324827.3, ENST00000313871.9
    Conserved Domains (3) summary
    cd12264
    Location:143265
    RRM_AKAP17A; RNA recognition motif found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins
    cd16269
    Location:424433
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:345433
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_027383.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate coding exon that results in a frameshift and prematurely truncated open reading frame. The transcript is predicted to be subject to nonsense-mediated decay (NMD) and thus the predicted protein product is not annotated on the record.
    Source sequence(s)
    AL683807, BC015800, BC016935, BC028151, BC110497, L03426, M99578
    Related
    ENST00000474361.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1591604..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1591604..1602520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    1393022..1403889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1455997..1466654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)