U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ABCB19 ATP binding cassette subfamily B19 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822519, updated on 19-Feb-2025
Official Symbol
ABCB19
Official Full Name
ATP binding cassette subfamily B19
Primary source
TAIR:AT3G28860
Locus tag
AT3G28860
See related
Araport:AT3G28860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana ATP-binding cassette B19; ATABCB19; ATMDR1; ATMDR11; ATP binding cassette subfamily B19; ATP BINDING CASSETTE SUBFAMILY B19; ATP-binding cassette B19; ATPGP19; MDR1; MDR11; MULTIDRUG RESISTANCE PROTEIN 11; P-GLYCOPROTEIN 19; PGP19
Summary
Encodes a member of the ATP-binding cassette (ABC) transporter family that is involved in auxin transport and is involved in postembryonic organ separation. Also known as AtMDR11 and PGP19. Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Acts upstream of phyA in regulating hypocotyl elongation and gravitropic response. Exerts nonredundantly overlapping functions with the ABC transporter encoded by AtPGP1.
Try the new Gene page
Try the new Transcripts and proteins table
See ABCB19 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (10870005..10877578, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene basic helix-loop-helix (bHLH) DNA-binding family protein Neighboring gene pseudo Neighboring gene paired amphipathic helix SIN3-like protein

Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Ying W, et al. Science, 2024 Mar 22. PMID 38513023
  2. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Noh B, et al. Plant Cell, 2001 Nov. PMID 11701880, Free PMC Article
  3. Mutations in Arabidopsis multidrug resistance-like ABC transporters separate the roles of acropetal and basipetal auxin transport in lateral root development. Wu G, et al. Plant Cell, 2007 Jun. PMID 17557807, Free PMC Article
  4. The ABC subfamily B auxin transporter AtABCB19 is involved in the inhibitory effects of N-1-naphthyphthalamic acid on the phototropic and gravitropic responses of Arabidopsis hypocotyls. Nagashima A, et al. Plant Cell Physiol, 2008 Aug. PMID 18556728
  5. Auxin transport into cotyledons and cotyledon growth depend similarly on the ABCB19 Multidrug Resistance-like transporter. Lewis DR, et al. Plant J, 2009 Oct. PMID 19508431

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCB19 transporter: fostering brassinosteroid transport through membrane flexibility.
    Title: ABCB19 transporter: fostering brassinosteroid transport through membrane flexibility.
  2. Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
    Title: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
  3. ABCB19 is associated with cytoplasmic streaming and gravitropism in Arabidopsis.
    Title: An ABC transporter B family protein, ABCB19, is required for cytoplasmic streaming and gravitropism of the inflorescence stems.
  4. Data show ABCB19-mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle.
    Title: ABCB19-mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle.
  5. ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.
    Title: ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development.
  6. Ion channel activity of ABCB19 that is blocked by NPPB, a compound that can now be considered an inhibitor of polar auxin transport with a defined molecular target.
    Title: Block of ATP-binding cassette B19 ion channel activity by 5-nitro-2-(3-phenylpropylamino)-benzoic acid impairs polar auxin transport and root gravitropism.
  7. ABCB19 takes part in adventitious root formation in Arabidopsis.
    Title: Localized induction of the ATP-binding cassette B19 auxin transporter enhances adventitious root formation in Arabidopsis.
  8. The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis.
    Title: The ATP-binding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis.
  9. Structural sterols and sphingolipids regulate ABCB19-GFP trafficking between the trans-Golgi network and the plasma membrane.
    Title: Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter.
  10. Phosphorylation of ABCB19 by phot1 inhibits its efflux activity, thereby increasing auxin levels in and above the hypocotyl apex.
    Title: phot1 inhibition of ABCB19 primes lateral auxin fluxes in the shoot apex required for phototropism.
Submit: New GeneRIF Correction See all GeneRIFs (18)
Products Interactant Other Gene Complex Source Pubs Description
NM_113807.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables auxin efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acropetal auxin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anthocyanin accumulation in tissues in response to UV light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within auxin polar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within auxin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within basipetal auxin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within formation of plant organ boundary IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive gravitropism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to blue light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to red or far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stamen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
ATP binding cassette subfamily B19
NP_189528.1
  • ATP binding cassette subfamily B19 (ABCB19); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, auxin efflux transmembrane transporter activity; INVOLVED IN: in 14 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B1 (TAIR:AT2G36910.1); Has 832220 Blast hits to 388750 proteins in 4155 species: Archae - 14331; Bacteria - 653917; Metazoa - 17455; Fungi - 11958; Plants - 9253; Viruses - 33; Other Eukaryotes - 125273 (source: NCBI BLink).

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    10870005..10877578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113807.3 → NP_189528.1  ATP binding cassette subfamily B19 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189528.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GZ77, Q8H6F5, Q9LJX0
    UniProtKB/TrEMBL
    A0A5S9XGL2, A0A654FCP4
    Conserved Domains (1) summary
    PTZ00265
    Location:17 → 1247
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LJX0.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools