Format

Send to:

Choose Destination

GTPBP6 GTP binding protein 6 (putative) [ Homo sapiens (human) ]

Gene ID: 8225, updated on 1-Aug-2020

Summary

Official Symbol
GTPBP6provided by HGNC
Official Full Name
GTP binding protein 6 (putative)provided by HGNC
Primary source
HGNC:HGNC:30189
See related
Ensembl:ENSG00000178605 MIM:300124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGPL
Summary
This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in kidney (RPKM 14.1), spleen (RPKM 12.8) and 25 other tissues See more
Orthologs

Genomic context

See GTPBP6 in Genome Data Viewer
Location:
Xp22.33 and Yp11.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (303352..318819, complement)
109.20200522 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (303352..318819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (221426..230887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (171426..180887, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20977, FLJ22809, FLJ56662, FLJ56805, FLJ90047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative GTP-binding protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034126.1 RefSeqGene

    Range
    5001..19070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012227.3NP_036359.3  putative GTP-binding protein 6

    See identical proteins and their annotated locations for NP_036359.3

    Status: VALIDATED

    Source sequence(s)
    AK223412, BG437484, CN356690, CX758592
    Consensus CDS
    CCDS75943.1
    UniProtKB/Swiss-Prot
    O43824
    UniProtKB/TrEMBL
    H0Y2S1
    Related
    ENSP00000316598.5, ENST00000326153.9
    Conserved Domains (1) summary
    COG2262
    Location:116513
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    303352..318819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724447.4XP_006724510.1  putative GTP-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006724510.1

    Conserved Domains (4) summary
    cd01878
    Location:115316
    HflX; HflX GTPase family
    pfam02421
    Location:157311
    FeoB_N; Ferrous iron transport protein B
    pfam13167
    Location:169
    GTP-bdg_N; GTP-binding GTPase N-terminal
    pfam16360
    Location:73144
    GTP-bdg_M; GTP-binding GTPase Middle Region
  2. XM_011546184.3XP_011544486.1  putative GTP-binding protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011544486.1

    Conserved Domains (4) summary
    cd01878
    Location:74275
    HflX; HflX GTPase family
    pfam02421
    Location:116270
    FeoB_N; Ferrous iron transport protein B
    pfam13167
    Location:728
    GTP-bdg_N; GTP-binding GTPase N-terminal
    pfam16360
    Location:32103
    GTP-bdg_M; GTP-binding GTPase Middle Region

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    303352..318819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724868.4XP_006724931.1  putative GTP-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006724931.1

    Conserved Domains (4) summary
    cd01878
    Location:115316
    HflX; HflX GTPase family
    pfam02421
    Location:157311
    FeoB_N; Ferrous iron transport protein B
    pfam13167
    Location:169
    GTP-bdg_N; GTP-binding GTPase N-terminal
    pfam16360
    Location:73144
    GTP-bdg_M; GTP-binding GTPase Middle Region
  2. XM_011545637.3XP_011543939.1  putative GTP-binding protein 6 isoform X2

    See identical proteins and their annotated locations for XP_011543939.1

    Conserved Domains (4) summary
    cd01878
    Location:74275
    HflX; HflX GTPase family
    pfam02421
    Location:116270
    FeoB_N; Ferrous iron transport protein B
    pfam13167
    Location:728
    GTP-bdg_N; GTP-binding GTPase N-terminal
    pfam16360
    Location:32103
    GTP-bdg_M; GTP-binding GTPase Middle Region
Support Center