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MKK5 MAP kinase kinase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821676, updated on 15-Feb-2024

Summary

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Gene symbol
MKK5
Gene description
MAP kinase kinase 5
Primary source
Araport:AT3G21220
Locus tag
AT3G21220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5; ATMAP2K_ALPHA; ATMEK5; ATMKK5; MAP kinase kinase 5; MAP KINASE KINASE 5; MAP2K_A; MEK5
Summary
Encodes a mitogen-activated kinase kinase, dual specific protein kinase that is expressed in vegetative tissues and floral buds. Involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK4.In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.
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Genomic context

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Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (7445604..7448498)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene proton gradient regulation 7 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene 4-coumarate:CoA ligase 5 Neighboring gene 4-coumarate:CoA ligase 2 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis. Kim D, et al. Plant Cell, 2023 Apr 20. PMID 36762404, Free PMC Article
  2. Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis. Liu H, et al. Cell Res, 2008 Mar. PMID 18268539
  3. Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6. Li K, et al. Plant Signal Behav, 2017 May 4. PMID 28494202, Free PMC Article
  4. Regulation of floral organ abscission in Arabidopsis thaliana. Cho SK, et al. Proc Natl Acad Sci U S A, 2008 Oct 7. PMID 18809915, Free PMC Article
  5. Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity. Gao C, et al. J Integr Plant Biol, 2021 Feb. PMID 32877006

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.
    Title: The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.
  2. Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.
    Title: Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.
  3. The Arabidopsis MKK4/MKK5-MPK6 cascade is an important player in the maternal control of embryogenesis.
    Title: Maternal control of embryogenesis by MPK6 and its upstream MKK4/MKK5 in Arabidopsis.
  4. results indicated that AIK1-MKK5-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK cascade.
    Title: Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6.
  5. AIK1-MKK5-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
    Title: AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade.
  6. MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK signaling through MKK4/5/7/9-MPK3/6 cascades.
    Title: Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.
  7. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
    Title: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.
  8. our data indicate that EDR1 physically associates with MKK4/MKK5 and negatively regulates the MAPK cascade to fine-tune plant innate immunity.
    Title: EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity.
  9. Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested.
    Title: MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.
  10. Results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
    Title: A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001338511.1
NM_113017.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within floral organ abscission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflorescence development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in plant-type hypersensitive response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ethylene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal complex patterning IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MAP kinase kinase 5
NP_001319606.1
  • MAP kinase kinase 5 (MKK5); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase 4 (TAIR:AT1G51660.1); Has 130143 Blast hits to 128581 proteins in 4761 species: Archae - 120; Bacteria - 15121; Metazoa - 48301; Fungi - 12721; Plants - 32333; Viruses - 542; Other Eukaryotes - 21005 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7445604..7448498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001338511.1 → NP_001319606.1  MAP kinase kinase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80398, Q8RXG3, Q96517
    UniProtKB/TrEMBL
    A0A178VIK5, A0A5S9XE64
    Conserved Domains (1) summary
    PLN00034
    Location:1 → 342
    PLN00034; mitogen-activated protein kinase kinase; Provisional

  2. NM_113017.4 → NP_188759.1  MAP kinase kinase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188759.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80398, Q8RXG3, Q96517
    UniProtKB/TrEMBL
    A0A178VIK5, A0A5S9XE64
    Conserved Domains (1) summary
    PLN00034
    Location:1 → 342
    PLN00034; mitogen-activated protein kinase kinase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RXG3.2

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