UBP14 ubiquitin-specific protease 14 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UBP14
Official Full Name: ubiquitin-specific protease 14
Primary source: TAIR:AT3G20630
Locus tag: AT3G20630
See related: Araport:AT3G20630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATUBP14; PER1; phosphate deficiency root hair defective1; TITAN6; TTN6; ubiquitin-specific protease 14
Summary: Encodes a ubiquitin-specific protease. Identical to TTN6. Loss of function mutations are embryo lethals, having development arrested at the preglobular/globular stage. Also involved in root responses to phosphate deficiency.
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Genomic context

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See UBP14 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 20

Sequence:: Chromosome: 3; NC_003074.8 (7202748..7208547, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBIQUITIN-SPECIFIC PROTEASE14 Interacts with ULTRAVIOLET-B INSENSITIVE4 to Regulate Endoreduplication and Cell and Organ Growth in Arabidopsis
Title: UBIQUITIN-SPECIFIC PROTEASE14 Interacts with ULTRAVIOLET-B INSENSITIVE4 to Regulate Endoreduplication and Cell and Organ Growth in Arabidopsis.
Study conclude that UBP14 function is crucial for adapting root development to the prevailing local availability of phosphate.
Title: Ubiquitin-specific protease 14 (UBP14) is involved in root responses to phosphate deficiency in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_112954.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables Met1-linked polyubiquitin deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables linear polyubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to gibberellin stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin-specific protease 14

NP_566666.2

ubiquitin-specific protease 14 (UBP14); CONTAINS InterPro DOMAIN/s: Zinc finger, UBP-type (InterPro:IPR001607), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394), UBA-like (InterPro:IPR009060), Ubiquitinyl hydrolase (InterPro:IPR016652); Has 2045 Blast hits to 1942 proteins in 227 species: Archae - 0; Bacteria - 2; Metazoa - 1042; Fungi - 463; Plants - 217; Viruses - 0; Other Eukaryotes - 321 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

7202748..7208547 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112954.4 → NP_566666.2 ubiquitin-specific protease 14 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566666.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WV77, Q8L6Y1, Q9FPT0, Q9LJT6

UniProtKB/TrEMBL

A0A178VC00, A0A654FB00, A0A7G2ERF1

Conserved Domains (2) summary

COG5207
Location:1 → 796

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02658
Location:309 → 794

Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...