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MSH2 MUTS homolog 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821383, updated on 11-Oct-2018

Summary

Gene symbol
MSH2
Gene description
MUTS homolog 2
Primary source
Araport:AT3G18524
Locus tag
AT3G18524
Gene type
protein coding
RNA name
MUTS homolog 2
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMSH2; MUTS homolog 2
Summary
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.

Genomic context

See MSH2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (6367941..6372685, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ROTUNDIFOLIA like 20 Neighboring gene histone deacetylase 15 Neighboring gene ARM repeat superfamily protein Neighboring gene tubulin-tyrosine ligase Neighboring gene ncRNA

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MSH2 gene: The MSH2 gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs
NM_113607.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatched DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single thymine insertion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine dimer repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MUTS homolog 2
NP_566804.3
  • MUTS homolog 2 (MSH2); FUNCTIONS IN: damaged DNA binding, protein binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, negative regulation of reciprocal meiotic recombination; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein, MSH2 (InterPro:IPR011184); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 13560 Blast hits to 13453 proteins in 2654 species: Archae - 128; Bacteria - 8942; Metazoa - 734; Fungi - 813; Plants - 457; Viruses - 3; Other Eukaryotes - 2483 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6367941..6372685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113607.4NP_566804.3  MUTS homolog 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566804.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24617
    Conserved Domains (7) summary
    cd03285
    Location:630858
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:37898
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:22129
    MutS_I; MutS domain I
    pfam05188
    Location:143277
    MutS_II; MutS domain II
    pfam05190
    Location:468565
    MutS_IV; MutS family domain IV
    pfam05192
    Location:299380
    MutS_III; MutS domain III
    pfam05461
    Location:844930
    ApoL; Apolipoprotein L
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