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NRIP1 nuclear receptor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 8204, updated on 2-Oct-2018

Summary

Official Symbol
NRIP1provided by HGNC
Official Full Name
nuclear receptor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:8001
See related
Ensembl:ENSG00000180530 MIM:602490; Vega:OTTHUMG00000074323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP140
Summary
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 19.2), endometrium (RPKM 12.9) and 25 other tissues See more
Orthologs

Genomic context

See NRIP1 in Genome Data Viewer
Location:
21q11.2-q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (14961235..15065903, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (16333556..16438224, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 2246 Neighboring gene RBMX2 pseudogene 1 Neighboring gene uncharacterized LOC107985483 Neighboring gene uncharacterized LOC105369292

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA upregulates NRIP1 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ77253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid X receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
lipid storage IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
ovarian follicle rupture IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor-interacting protein 1
Names
nuclear factor RIP140
receptor-interacting protein 140

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050643.1 RefSeqGene

    Range
    6099..109669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003489.3NP_003480.2  nuclear receptor-interacting protein 1

    See identical proteins and their annotated locations for NP_003480.2

    Status: REVIEWED

    Source sequence(s)
    AF127577, AK289786, BC040361
    Consensus CDS
    CCDS13568.1
    UniProtKB/Swiss-Prot
    P48552
    UniProtKB/TrEMBL
    A8K171
    Related
    ENSP00000327213.4, ENST00000318948.6
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    14961235..15065903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529752.1XP_011528054.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528054.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  2. XM_011529747.1XP_011528049.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528049.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  3. XM_017028475.1XP_016883964.1  nuclear receptor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  4. XM_011529748.2XP_011528050.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528050.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  5. XM_017028473.1XP_016883962.1  nuclear receptor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  6. XM_005261065.3XP_005261122.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005261122.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  7. XM_005261063.3XP_005261120.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005261120.1

    UniProtKB/Swiss-Prot
    P48552
    Related
    ENSP00000383060.1, OTTHUMP00000083036, ENST00000400199.5, OTTHUMT00000157925
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  8. XM_017028476.1XP_016883965.1  nuclear receptor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  9. XM_011529749.2XP_011528051.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528051.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  10. XM_011529751.2XP_011528053.1  nuclear receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528053.1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
  11. XM_017028474.1XP_016883963.1  nuclear receptor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P48552
    Conserved Domains (4) summary
    pfam15687
    Location:27330
    NRIP1_repr_1; Nuclear receptor-interacting protein 1 repression 1
    pfam15688
    Location:411738
    NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    pfam15689
    Location:753840
    NRIP1_repr_3; Nuclear receptor-interacting protein 1 repression 3
    pfam15690
    Location:8491158
    NRIP1_repr_4; Nuclear receptor-interacting protein 1 repression 4
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