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NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

Gene ID: 8202, updated on 8-Oct-2017
Official Symbol
NCOA3provided by HGNC
Official Full Name
nuclear receptor coactivator 3provided by HGNC
Primary source
HGNC:HGNC:7670
See related
Ensembl:ENSG00000124151 MIM:601937; Vega:OTTHUMG00000033061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Orthologs
Location:
20q13.12
Exon count:
23
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (47501857..47656877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130601..46285621)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 497, pseudogene Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene sulfatase 2 Neighboring gene uncharacterized LOC107985401 Neighboring gene RNA, U7 small nuclear 173 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
    Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
    Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystemIn mammals, anterior Hox genes may be defined as paralog groups 1 to 4 (Natale et al. 2011), which are involved in development of the hindbrain through sequential expression in the rhombomeres, trans...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    FOXA1 transcription factor network, organism-specific biosystem
    FOXA1 transcription factor network
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Retinoic acid receptors-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Retinoic acid receptors-mediated signaling, organism-specific biosystem
    Retinoic acid receptors-mediated signaling
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC141848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core binding ISS
Inferred from Sequence or Structural Similarity
more info
 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-dependent nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligand-dependent nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell dedifferentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
receptor transactivation TAS
Traceable Author Statement
more info
PubMed 
regulation of RNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
nuclear receptor coactivator 3
Names
CBP-interacting protein
amplified in breast cancer 1 protein
class E basic helix-loop-helix protein 42
receptor-associated coactivator 3
steroid receptor coactivator protein 3
thyroid hormone receptor activator molecule 1
NP_001167558.1
NP_001167559.1
NP_006525.2
NP_858045.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016810.1 RefSeqGene

    Range
    5001..160021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174087.1NP_001167558.1  nuclear receptor coactivator 3 isoform c

    See identical proteins and their annotated locations for NP_001167558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AB209863, AL034418, DB091786
    UniProtKB/TrEMBL
    Q59EE8
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam00989
    Location:117215
    PAS; PAS fold
    pfam07469
    Location:12901347
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. NM_001174088.1NP_001167559.1  nuclear receptor coactivator 3 isoform d

    See identical proteins and their annotated locations for NP_001167559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
    Source sequence(s)
    AF036892, AL034418, DB091786
    Consensus CDS
    CCDS54472.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Related
    ENSP00000361065.3, OTTHUMP00000031717, ENST00000371997.3, OTTHUMT00000080404
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam00989
    Location:117215
    PAS; PAS fold
    pfam07469
    Location:12821339
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10401087
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:630714
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265385
    PAS_11; PAS domain
    pfam16279
    Location:733820
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:469582
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. NM_006534.3NP_006525.2  nuclear receptor coactivator 3 isoform b

    See identical proteins and their annotated locations for NP_006525.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AF012108, AL034418, DB091786
    Consensus CDS
    CCDS13406.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Related
    ENSP00000361073.1, OTTHUMP00000031716, ENST00000372004.7, OTTHUMT00000080403
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam07469
    Location:12871344
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620704
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:10771364
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. NM_181659.2NP_858045.1  nuclear receptor coactivator 3 isoform a

    See identical proteins and their annotated locations for NP_858045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF016031, AL034418, DB091786
    Consensus CDS
    CCDS13407.1
    UniProtKB/Swiss-Prot
    Q9Y6Q9
    Related
    ENSP00000361066.3, OTTHUMP00000031718, ENST00000371998.7, OTTHUMT00000080405
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam00989
    Location:117215
    PAS; PAS fold
    pfam07469
    Location:12911348
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    47501857..47656877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    46033477..46188916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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