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NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

Gene ID: 8202, updated on 23-Nov-2023

Summary

Official Symbol
NCOA3provided by HGNC
Official Full Name
nuclear receptor coactivator 3provided by HGNC
Primary source
HGNC:HGNC:7670
See related
Ensembl:ENSG00000124151 MIM:601937; AllianceGenome:HGNC:7670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Annotation information
Note: RAC3 (Gene ID: 5881) and NCOA3 (Gene ID: 8202) share the RAC3 symbol/alias in common. RAC3 is a widely used alternative name for nuclear receptor coactivator 3 (NCOA3), which can be confused with the official symbol for ras-related C3 botulinum toxin substrate 3 (RAC3). [06 Jul 2018]
Expression
Ubiquitous expression in lymph node (RPKM 20.8), placenta (RPKM 19.0) and 25 other tissues See more
Orthologs
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Genomic context

See NCOA3 in Genome Data Viewer
Location:
20q13.12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47501887..47656872)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49240095..49395274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130631..46285616)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12979 Neighboring gene RNA, U6 small nuclear 497, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr20.2047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12980 Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46152763-46153530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46158187-46158687 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:46190110-46190292 Neighboring gene MPRA-validated peak4234 silencer Neighboring gene ribosomal protein S3A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46276897-46277614 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46277615-46278332 Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46293563-46294548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46294549-46295532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46303203-46304168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46307531-46308031 Neighboring gene sulfatase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46316712-46317262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46317263-46317814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46326206-46326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339340-46339840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339841-46340341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381087-46381588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381589-46382088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386138-46386895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386896-46387654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46387655-46388411 Neighboring gene NANOG hESC enhancer GRCh37_chr20:46390145-46390683 Neighboring gene Sharpr-MPRA regulatory region 8498 Neighboring gene uncharacterized LOC124904922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18007 Neighboring gene uncharacterized LOC124904920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18008

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
EBI GWAS Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC141848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 3
Names
CBP-interacting protein
amplified in breast cancer 1 protein
class E basic helix-loop-helix protein 42
receptor-associated coactivator 3
steroid receptor coactivator protein 3
thyroid hormone receptor activator molecule 1
NP_001167558.1
NP_001167559.1
NP_006525.2
NP_858045.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016810.2 RefSeqGene

    Range
    5002..159987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174087.2NP_001167558.1  nuclear receptor coactivator 3 isoform c

    See identical proteins and their annotated locations for NP_001167558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    UniProtKB/TrEMBL
    Q569F6
    Conserved Domains (8) summary
    smart00091
    Location:116173
    PAS; PAS domain
    cd18949
    Location:29101
    bHLH-PAS_NCoA3_SRC3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 3 (NCoA-3) and similar proteins
    pfam07469
    Location:12901347
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451091
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:616704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. NM_001174088.2NP_001167559.1  nuclear receptor coactivator 3 isoform d

    See identical proteins and their annotated locations for NP_001167559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS54472.1
    UniProtKB/TrEMBL
    Q0IIN7
    Related
    ENSP00000361065.3, ENST00000371997.3
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam00989
    Location:117215
    PAS; PAS fold
    pfam07469
    Location:12821339
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10401087
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:630714
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265385
    PAS_11; PAS domain
    pfam16279
    Location:733820
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:469582
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. NM_006534.4NP_006525.2  nuclear receptor coactivator 3 isoform b

    See identical proteins and their annotated locations for NP_006525.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS13406.1
    UniProtKB/TrEMBL
    Q0IIN7
    Related
    ENSP00000361073.1, ENST00000372004.7
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam07469
    Location:12871344
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620704
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:10771364
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  4. NM_181659.3NP_858045.1  nuclear receptor coactivator 3 isoform a

    See identical proteins and their annotated locations for NP_858045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS13407.1
    UniProtKB/Swiss-Prot
    A4LAZ5, Q0VF45, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7, Q9Y6Q9
    UniProtKB/TrEMBL
    A8K0W8
    Related
    ENSP00000361066.3, ENST00000371998.8
    Conserved Domains (9) summary
    smart00353
    Location:3488
    HLH; helix loop helix domain
    smart00091
    Location:116173
    PAS; PAS domain
    pfam00989
    Location:117215
    PAS; PAS fold
    pfam07469
    Location:12911348
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:10451092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265375
    PAS_11; PAS domain
    pfam16279
    Location:723810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    47501887..47656872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    49240095..49395274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)