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ERCC1 nucleotide repair protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819685, updated on 7-Sep-2023

Summary

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Gene symbol
ERCC1
Gene description
nucleotide repair protein
Primary source
Araport:AT3G05210
Locus tag
AT3G05210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T12H1.18; T12H1_18; UV REPAIR DEFICIENT 7; UVR7
Summary
encodes a homolog of human ERCC1 protein (yeast RAD10), which is a DNA repair endonuclease. Mutants are sensitive to UV-B and gamma radiation (G2 cell cycle phase arrest) and are defective in dark-repair of pyrimidine pyrimidone dimers. This protein incises the 5' end of damaged DNA, similar to ERCC1/RAD10.
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Genomic context

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Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (1479339..1482042)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Signal peptidase subunit Neighboring gene mitochondrial editing factor 19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of the AtErcc1 protein in recombination. Dubest S, et al. Plant J, 2004 Aug. PMID 15255863
  2. Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1. Hefner E, et al. J Exp Bot, 2003 Feb. PMID 12554710
  3. ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana. Vannier JB, et al. PLoS Genet, 2009 Feb. PMID 19214203, Free PMC Article
  4. UV- and gamma-radiation sensitive mutants of Arabidopsis thaliana. Jiang CZ, et al. Genetics, 1997 Nov. PMID 9383080, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERCC1 and XPF protect short telomeres from homologous recombination.
    Title: ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111394.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 5'-flap endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within non-photoreactive DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleotide-excision repair, preincision complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nucleotide repair protein
NP_187172.1
  • ERCC1; FUNCTIONS IN: 5'-flap endonuclease activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), DNA repair protein rad10 (InterPro:IPR004579), RuvA domain 2-like (InterPro:IPR010994); Has 658 Blast hits to 452 proteins in 188 species: Archae - 0; Bacteria - 4; Metazoa - 166; Fungi - 153; Plants - 44; Viruses - 0; Other Eukaryotes - 291 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1479339..1482042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337571.1 → NP_001327616.1  nucleotide repair protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LSV8
    Conserved Domains (1) summary
    cd22325
    Location:124 → 251
    ERCC1_C-like; Central domain of ERCC1

  2. NM_111394.5 → NP_187172.1  nucleotide repair protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9MA98
    UniProtKB/TrEMBL
    A0A178VL77, A0A5S9X985, A0A654F482
    Conserved Domains (2) summary
    cl22429
    Location:266 → 317
    HHH_5; Helix-hairpin-helix domain
    cl40440
    Location:124 → 251
    PDDEXK_nuclease-like; PDDEXK family nucleases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MA98.1

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