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KIF18A kinesin family member 18A [ Homo sapiens (human) ]

Gene ID: 81930, updated on 7-Apr-2025

Summary

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Official Symbol
KIF18Aprovided by HGNC
Official Full Name
kinesin family member 18Aprovided by HGNC
Primary source
HGNC:HGNC:29441
See related
Ensembl:ENSG00000121621 MIM:611271; AllianceGenome:HGNC:29441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R99; MS-KIF18A
Summary
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues See more
Orthologs
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Genomic context

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See KIF18A in Genome Data Viewer
Location:
11p14.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (28020619..28108156, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (28161289..28248842, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (28042166..28129703, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902654 Neighboring gene uncharacterized LOC124902655 Neighboring gene microRNA 610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28128916-28129440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28129441-28129964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4549 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28131476-28131976 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:28161954-28163153 Neighboring gene methyltransferase 15, mitochondrial 12S rRNA N4-cytidine Neighboring gene MPRA-validated peak1236 silencer Neighboring gene ATP synthase membrane subunit g pseudogene 8 Neighboring gene RN7SK pseudogene 158

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A. Stumpff J, et al. Mol Cell, 2011 Sep 2. PMID 21884977, Free PMC Article
  2. Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line. Smialek MJ, et al. J Cell Sci, 2020 Apr 6. PMID 32094263
  3. Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases. Guo W, et al. Medicine (Baltimore), 2020 Jan. PMID 31977917, Free PMC Article
  4. Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo. Chen FT, et al. Dis Markers, 2019. PMID 31772692, Free PMC Article
  5. Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer. Zhang H, et al. Med Sci Monit, 2019 Aug 27. PMID 31451680, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE.
    Title: KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE.
  2. Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.
    Title: Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.
  3. KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
    Title: KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
  4. Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.
    Title: Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.
  5. Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
    Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
  6. Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
    Title: Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
  7. KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
    Title: KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
  8. Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.
    Title: Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.
  9. Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
    Title: Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
  10. this study showed that KIF18A is overexpressed in patients with LUAD, further confirming that a high KIF18A expression level is correlated with higher pathologic tumor status stage, poorer tumor differentiation, lymph node metastasis, and tumor stage.
    Title: High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434G2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitotic metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within seminiferous tubule development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle midzone IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF18A
Names
protein phosphatase 1, regulatory subunit 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031217.4 → NP_112494.3  kinesin-like protein KIF18A

    See identical proteins and their annotated locations for NP_112494.3

    Status: VALIDATED

    Source sequence(s)
    AL136819, AW770226, DB080843
    Consensus CDS
    CCDS7867.1
    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3
    Related
    ENSP00000263181.6, ENST00000263181.7
    Conserved Domains (2) summary
    cd01370
    Location:11 → 355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17 → 355
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    28020619..28108156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018379.2 → XP_016873868.1  kinesin-like protein KIF18A isoform X1

    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3
    Conserved Domains (2) summary
    cd01370
    Location:11 → 355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17 → 355
    Kinesin; Kinesin motor domain

  2. XM_017018380.2 → XP_016873869.1  kinesin-like protein KIF18A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    28161289..28248842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370093.1 → XP_054226068.1  kinesin-like protein KIF18A isoform X1

    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3

  2. XM_054370094.1 → XP_054226069.1  kinesin-like protein KIF18A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NI77.2 GenPept UniProtKB/Swiss-Prot:Q8NI77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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