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KIF18A kinesin family member 18A [ Homo sapiens (human) ]

Gene ID: 81930, updated on 1-Jun-2020

Summary

Official Symbol
KIF18Aprovided by HGNC
Official Full Name
kinesin family member 18Aprovided by HGNC
Primary source
HGNC:HGNC:29441
See related
Ensembl:ENSG00000121621 MIM:611271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R99; MS-KIF18A
Summary
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues See more
Orthologs

Genomic context

See KIF18A in Genome Data Viewer
Location:
11p14.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (28020619..28108180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (28042163..28129746, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromobox 3 pseudogene 1 Neighboring gene heat shock protein 90 alpha family class A member 2, pseudogene Neighboring gene microRNA 610 Neighboring gene methyltransferase like 15 Neighboring gene ATP synthase membrane subunit g pseudogene 8 Neighboring gene RN7SK pseudogene 158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434G2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-dependent microtubule motor activity, plus-end-directed IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
 
mitotic metaphase plate congression IDA
Inferred from Direct Assay
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
seminiferous tubule development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF18A
Names
protein phosphatase 1, regulatory subunit 99

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031217.4NP_112494.3  kinesin-like protein KIF18A

    See identical proteins and their annotated locations for NP_112494.3

    Status: VALIDATED

    Source sequence(s)
    AL136819, AW770226, DB080843
    Consensus CDS
    CCDS7867.1
    UniProtKB/Swiss-Prot
    Q8NI77
    Related
    ENSP00000263181.6, ENST00000263181.7
    Conserved Domains (2) summary
    cd01370
    Location:11355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17355
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    28020619..28108180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018379.1XP_016873868.1  kinesin-like protein KIF18A isoform X1

    UniProtKB/Swiss-Prot
    Q8NI77
    Conserved Domains (2) summary
    cd01370
    Location:11355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17355
    Kinesin; Kinesin motor domain
  2. XM_017018380.1XP_016873869.1  kinesin-like protein KIF18A isoform X2

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