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KIF18A kinesin family member 18A [ Homo sapiens (human) ]

Gene ID: 81930, updated on 9-Jun-2024

Summary

Official Symbol
KIF18Aprovided by HGNC
Official Full Name
kinesin family member 18Aprovided by HGNC
Primary source
HGNC:HGNC:29441
See related
Ensembl:ENSG00000121621 MIM:611271; AllianceGenome:HGNC:29441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R99; MS-KIF18A
Summary
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues See more
Orthologs
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Genomic context

See KIF18A in Genome Data Viewer
Location:
11p14.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (28020619..28108156, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (28161289..28248842, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (28042166..28129703, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902654 Neighboring gene uncharacterized LOC124902655 Neighboring gene microRNA 610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28128916-28129440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28129441-28129964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4549 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:28131476-28131976 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:28161954-28163153 Neighboring gene methyltransferase 15, mitochondrial 12S rRNA N4-cytidine Neighboring gene MPRA-validated peak1236 silencer Neighboring gene ATP synthase membrane subunit g pseudogene 8 Neighboring gene RN7SK pseudogene 158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434G2226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic metaphase chromosome alignment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in seminiferous tubule development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF18A
Names
protein phosphatase 1, regulatory subunit 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031217.4NP_112494.3  kinesin-like protein KIF18A

    See identical proteins and their annotated locations for NP_112494.3

    Status: VALIDATED

    Source sequence(s)
    AL136819, AW770226, DB080843
    Consensus CDS
    CCDS7867.1
    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3
    Related
    ENSP00000263181.6, ENST00000263181.7
    Conserved Domains (2) summary
    cd01370
    Location:11355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17355
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    28020619..28108156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018379.2XP_016873868.1  kinesin-like protein KIF18A isoform X1

    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3
    Conserved Domains (2) summary
    cd01370
    Location:11355
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    pfam00225
    Location:17355
    Kinesin; Kinesin motor domain
  2. XM_017018380.2XP_016873869.1  kinesin-like protein KIF18A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    28161289..28248842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370093.1XP_054226068.1  kinesin-like protein KIF18A isoform X1

    UniProtKB/Swiss-Prot
    Q4VPE3, Q86VS5, Q8NI77, Q9H0F3
    UniProtKB/TrEMBL
    B2R6H3
  2. XM_054370094.1XP_054226069.1  kinesin-like protein KIF18A isoform X2