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DHDPS2 dihydrodipicolinate synthase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819152, updated on 11-Jun-2025
Official Symbol
DHDPS2
Official Full Name
dihydrodipicolinate synthase
Primary source
TAIR:AT2G45440
Locus tag
AT2G45440
See related
Araport:AT2G45440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
dihydrodipicolinate synthase; dihydrodipicolinate synthase 2; F4L23.5
Summary
Encodes a protein that likely has dihydropicolinate synthase activity based on its mutant phenotype of decreased lysine levels and increased aspartate levels. The mutant also has increased levels of threonine. The enzyme is predicted to localize to the chloroplast.
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See DHDPS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (18730840..18733119)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AT-hook motif nuclear-localized protein 22 Neighboring gene binding protein Neighboring gene SMAD/FHA domain-containing protein

Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana. Griffin MD, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Nov 1. PMID 22102238, Free PMC Article
  2. Identification of an Arabidopsis thaliana mutant accumulating threonine resulting from mutation in a new dihydrodipicolinate synthase gene. Sarrobert C, et al. Plant J, 2000 Nov. PMID 11069709
  3. Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana. Griffin MD, et al. PLoS One, 2012. PMID 22792278, Free PMC Article
  4. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_130106.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-hydroxy-tetrahydrodipicolinate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxy-tetrahydrodipicolinate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
Preferred Names
dihydrodipicolinate synthase
NP_182068.1
  • dihydrodipicolinate synthase (DHDPS2); FUNCTIONS IN: dihydrodipicolinate synthase activity; INVOLVED IN: lysine biosynthetic process via diaminopimelate, metabolic process, diaminopimelate biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Dihydrodipicolinate synthase subfamily (InterPro:IPR005263), Dihydrodipicolinate synthetase (InterPro:IPR002220), Dihydrodipicolinate synthetase, active site (InterPro:IPR020625), Dihydrodipicolinate synthetase, conserved site (InterPro:IPR020624); BEST Arabidopsis thaliana protein match is: dihydrodipicolinate synthase 1 (TAIR:AT3G60880.2); Has 13334 Blast hits to 13334 proteins in 2656 species: Archae - 353; Bacteria - 9459; Metazoa - 101; Fungi - 305; Plants - 96; Viruses - 0; Other Eukaryotes - 3020 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18730840..18733119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130106.3 → NP_182068.1  dihydrodipicolinate synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22129, Q9FVC8
    UniProtKB/TrEMBL
    A0A178VXY0, A0A384KQ79, A0A654F7D0, A0A7G2EK59, Q0WSN6
    Conserved Domains (1) summary
    PLN02417
    Location:64 → 343
    PLN02417; dihydrodipicolinate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FVC8.2

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