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SLC25A28 solute carrier family 25 member 28 [ Homo sapiens (human) ]

Gene ID: 81894, updated on 4-Dec-2022

Summary

Official Symbol
SLC25A28provided by HGNC
Official Full Name
solute carrier family 25 member 28provided by HGNC
Primary source
HGNC:HGNC:23472
See related
Ensembl:ENSG00000155287 MIM:609767; AllianceGenome:HGNC:23472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFRN2; MRS4L; MRS3/4; NPD016
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), testis (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See SLC25A28 in Genome Data Viewer
Location:
10q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (99610522..99659286, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (100493405..100503319, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101370279..101380196, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 3 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105378450 Neighboring gene Sharpr-MPRA regulatory region 10719 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene EBAG9 pseudogene 1 Neighboring gene cytochrome c oxidase assembly homolog COX15 Neighboring gene cutC copper transporter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
EBI GWAS Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547C109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitoferrin-2
Names
hMRS3/4
mitochondrial RNA splicing protein 3/4
mitochondrial RNA-splicing protein 3/4 homolog
mitochondrial iron transporter 2
putative mitochondrial solute carrier
solute carrier family 25 (mitochondrial iron transporter), member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031212.4NP_112489.3  mitoferrin-2

    See identical proteins and their annotated locations for NP_112489.3

    Status: VALIDATED

    Source sequence(s)
    BC047312, CD672723
    Consensus CDS
    CCDS41559.1
    UniProtKB/Swiss-Prot
    Q96A46, Q9H2J3
    Related
    ENSP00000359526.4, ENST00000370495.6
    Conserved Domains (1) summary
    pfam00153
    Location:71161
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    99610522..99659286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718005.5XP_006718068.1  mitoferrin-2 isoform X2

    See identical proteins and their annotated locations for XP_006718068.1

    Conserved Domains (1) summary
    pfam00153
    Location:70154
    Mito_carr; Mitochondrial carrier protein
  2. XM_024448223.2XP_024303991.1  mitoferrin-2 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:70154
    Mito_carr; Mitochondrial carrier protein
  3. XM_024448222.2XP_024303990.1  mitoferrin-2 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:70154
    Mito_carr; Mitochondrial carrier protein
  4. XM_005270211.6XP_005270268.1  mitoferrin-2 isoform X2

    See identical proteins and their annotated locations for XP_005270268.1

    Related
    ENSP00000514891.1, ENST00000700251.1
    Conserved Domains (1) summary
    pfam00153
    Location:70154
    Mito_carr; Mitochondrial carrier protein
  5. XM_047425809.1XP_047281765.1  mitoferrin-2 isoform X2

  6. XM_011540239.2XP_011538541.1  mitoferrin-2 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:79163
    Mito_carr; Mitochondrial carrier protein
  7. XM_047425810.1XP_047281766.1  mitoferrin-2 isoform X3

  8. XM_011540244.3XP_011538546.1  mitoferrin-2 isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:71161
    Mito_carr; Mitochondrial carrier protein
  9. XM_006718006.4XP_006718069.1  mitoferrin-2 isoform X5

    See identical proteins and their annotated locations for XP_006718069.1

    Conserved Domains (1) summary
    pfam00153
    Location:71161
    Mito_carr; Mitochondrial carrier protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    100493405..100503319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)