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QTRT1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Homo sapiens (human) ]

Gene ID: 81890, updated on 13-May-2022

Summary

Official Symbol
QTRT1provided by HGNC
Official Full Name
queuine tRNA-ribosyltransferase catalytic subunit 1provided by HGNC
Primary source
HGNC:HGNC:23797
See related
Ensembl:ENSG00000213339 MIM:609615; AllianceGenome:HGNC:23797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGT; TGUT; FP3235
Summary
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See QTRT1 in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10701439..10713365)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10827905..10839826)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10812115..10824041)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ILF3 divergent transcript Neighboring gene interleukin enhancer binding factor 3 Neighboring gene microRNA 638 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC124904637

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables queuine tRNA-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables queuine tRNA-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables queuine tRNA-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA modification TAS
Traceable Author Statement
more info
PubMed 
involved_in tRNA-guanine transglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA-guanine transglycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA-guanine transglycosylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IC
Inferred by Curator
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transferase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
queuine tRNA-ribosyltransferase catalytic subunit 1
Names
TGT, 43-KD subunit
TGT, catalytic subunit
guanine insertion enzyme
queuine tRNA-ribosyltransferase 1
tRNA-guanine transglycosylase
NP_112486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031209.3NP_112486.1  queuine tRNA-ribosyltransferase catalytic subunit 1

    See identical proteins and their annotated locations for NP_112486.1

    Status: REVIEWED

    Source sequence(s)
    AF302783, AF370379, CT003728
    Consensus CDS
    CCDS12248.1
    UniProtKB/Swiss-Prot
    Q9BXR0
    UniProtKB/TrEMBL
    Q71RF8
    Related
    ENSP00000250237.4, ENST00000250237.10
    Conserved Domains (1) summary
    cl19224
    Location:26376
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10701439..10713365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10827905..10839826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)