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QTRT1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Homo sapiens (human) ]

Gene ID: 81890, updated on 5-Jul-2025
Official Symbol
QTRT1provided by HGNC
Official Full Name
queuine tRNA-ribosyltransferase catalytic subunit 1provided by HGNC
Primary source
HGNC:HGNC:23797
See related
Ensembl:ENSG00000213339 MIM:609615; AllianceGenome:HGNC:23797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGT; TGUT; FP3235
Summary
This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues See more
Orthologs
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See QTRT1 in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10701439..10713365)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10827905..10839826)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10812115..10824041)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763030-10763532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763533-10764034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10087 Neighboring gene ILF3 divergent transcript Neighboring gene interleukin enhancer binding factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10801737-10802532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10802533-10803326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10806023-10806522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10811832-10812580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13985 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10826293-10826482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13990 Neighboring gene microRNA 638 Neighboring gene dynamin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10859277-10860091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10861227-10861848 Neighboring gene uncharacterized LOC124904637

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA-guanosine(34) queuine transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA-guanosine(34) queuine transglycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA-guanosine(34) queuine transglycosylase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-guanosine(34) queuine transglycosylase activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble guanine modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA wobble guanine modification TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
colocalizes_with mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of tRNA-guanine transglycosylase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
queuine tRNA-ribosyltransferase catalytic subunit 1
Names
TGT, 43-KD subunit
TGT, catalytic subunit
guanine insertion enzyme
queuine tRNA-ribosyltransferase 1
tRNA-guanine transglycosylase
NP_112486.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031209.3NP_112486.1  queuine tRNA-ribosyltransferase catalytic subunit 1

    See identical proteins and their annotated locations for NP_112486.1

    Status: REVIEWED

    Source sequence(s)
    AF302783, AF370379, CT003728
    Consensus CDS
    CCDS12248.1
    UniProtKB/Swiss-Prot
    B4DFM7, Q96BQ4, Q9BXQ9, Q9BXR0
    UniProtKB/TrEMBL
    B2RAR3
    Related
    ENSP00000250237.4, ENST00000250237.10
    Conserved Domains (1) summary
    cl19224
    Location:26376
    TGT; Queuine tRNA-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10701439..10713365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10827905..10839826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)