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SYMPK symplekin [ Homo sapiens (human) ]

Gene ID: 8189, updated on 1-Jun-2020

Summary

Official Symbol
SYMPKprovided by HGNC
Official Full Name
symplekinprovided by HGNC
Primary source
HGNC:HGNC:22935
See related
Ensembl:ENSG00000125755 MIM:602388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPK; SYM
Summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 32.3), spleen (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See SYMPK in Genome Data Viewer
Location:
19q13.32
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45815410..45863167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46318700..46366548, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DM1 locus, WD repeat containing Neighboring gene radial spoke head 6 homolog A Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene forkhead box A3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004819.3NP_004810.2  symplekin

    See identical proteins and their annotated locations for NP_004810.2

    Status: REVIEWED

    Source sequence(s)
    AC092301, BC006536, BU752018, DB044963, Y10931
    Consensus CDS
    CCDS12676.2
    UniProtKB/Swiss-Prot
    Q92797
    UniProtKB/TrEMBL
    A0A024R0R6
    Related
    ENSP00000245934.7, ENST00000245934.12
    Conserved Domains (3) summary
    pfam11935
    Location:121349
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:8871068
    Symplekin_C; Symplekin tight junction protein C terminal
    cl21453
    Location:833888
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45815410..45863167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259286.1XP_005259343.1  symplekin isoform X1

    See identical proteins and their annotated locations for XP_005259343.1

    UniProtKB/Swiss-Prot
    Q92797
    UniProtKB/TrEMBL
    A0A024R0R6
    Conserved Domains (3) summary
    pfam11935
    Location:121349
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:8871068
    Symplekin_C; Symplekin tight junction protein C terminal
    cl21453
    Location:833888
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011527354.1XP_011525656.1  symplekin isoform X1

    See identical proteins and their annotated locations for XP_011525656.1

    UniProtKB/Swiss-Prot
    Q92797
    UniProtKB/TrEMBL
    A0A024R0R6
    Conserved Domains (3) summary
    pfam11935
    Location:121349
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:8871068
    Symplekin_C; Symplekin tight junction protein C terminal
    cl21453
    Location:833888
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_243962.3 RNA Sequence

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