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HYI hydroxypyruvate isomerase (putative) [ Homo sapiens (human) ]

Gene ID: 81888, updated on 24-Nov-2020

Summary

Official Symbol
HYIprovided by HGNC
Official Full Name
hydroxypyruvate isomerase (putative)provided by HGNC
Primary source
HGNC:HGNC:26948
See related
Ensembl:ENSG00000178922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HT036
Summary
This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in fat (RPKM 17.6), duodenum (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See HYI in Genome Data Viewer
Location:
1p34.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43450607..43454241, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43916674..43919938, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MED8 antisense RNA 1 Neighboring gene mediator complex subunit 8 Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene SZT2 antisense RNA 1 Neighboring gene microRNA 6735 Neighboring gene Sharpr-MPRA regulatory region 4928 Neighboring gene protein tyrosine phosphatase receptor type F

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20767

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydroxypyruvate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
glyoxylate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
putative hydroxypyruvate isomerase
Names
endothelial cell apoptosis protein E-CE1
hydroxypyruvate isomerase homolog
NP_001177809.1
NP_001230455.1
NP_001317455.1
NP_112484.3
XP_006711000.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190880.3NP_001177809.1  putative hydroxypyruvate isomerase isoform 3

    See identical proteins and their annotated locations for NP_001177809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains two alternate splice junctions compared to variant 5. The resulting isoform (3) contains an alternate internal segment and lacks another alternate internal segment compared to isoform 5.
    Source sequence(s)
    AI023272, AL583862, BC006140, BC019041, BM715679
    Consensus CDS
    CCDS53309.1
    UniProtKB/Swiss-Prot
    Q5T013
    Related
    ENSP00000361502.4, ENST00000372425.8
    Conserved Domains (2) summary
    COG3622
    Location:3266
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    pfam01261
    Location:24230
    AP_endonuc_2; Xylose isomerase-like TIM barrel
  2. NM_001243526.2NP_001230455.1  putative hydroxypyruvate isomerase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate splice junction in the 3' end compared to variant 5. The resulting isoform (4) is shorter at the C-terminus compared to isoform 5.
    Source sequence(s)
    AI023272, AL583862, BC019041, BM715679, BM826556
    Consensus CDS
    CCDS72771.1
    UniProtKB/Swiss-Prot
    Q5T013
    UniProtKB/TrEMBL
    A0A0A0MTR5
    Related
    ENSP00000461969.2, ENST00000583037.5
    Conserved Domains (2) summary
    COG3622
    Location:3272
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    pfam01261
    Location:24255
    AP_endonuc_2; Xylose isomerase-like TIM barrel
  3. NM_001330526.2NP_001317455.1  putative hydroxypyruvate isomerase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AL583862
    Consensus CDS
    CCDS81313.1
    UniProtKB/TrEMBL
    F6UJY1
    Related
    ENSP00000361511.1, ENST00000372434.5
    Conserved Domains (2) summary
    COG3622
    Location:3291
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    pfam01261
    Location:24255
    AP_endonuc_2; Xylose isomerase-like TIM barrel
  4. NM_031207.6NP_112484.3  putative hydroxypyruvate isomerase isoform 1

    See identical proteins and their annotated locations for NP_112484.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains two alternate splice junctions and lacks an alternate in-frame coding exon compared to variant 5. The resulting isoform (1) contains an alternate internal segment, lacks another alternate internal segment, and is shorter at the C-terminus compared to isoform 5.
    Source sequence(s)
    AI023272, AL583862, AY037165, BM715679
    Consensus CDS
    CCDS488.2
    UniProtKB/Swiss-Prot
    Q5T013
    Related
    ENSP00000361509.1, ENST00000372432.5
    Conserved Domains (2) summary
    COG3622
    Location:3247
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    pfam01261
    Location:24230
    AP_endonuc_2; Xylose isomerase-like TIM barrel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43450607..43454241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710937.3XP_006711000.1  putative hydroxypyruvate isomerase isoform X1

    Conserved Domains (2) summary
    COG3622
    Location:3272
    Hyi; Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]
    pfam01261
    Location:24255
    AP_endonuc_2; Xylose isomerase-like TIM barrel
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