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LAS1L LAS1 like ribosome biogenesis factor [ Homo sapiens (human) ]

Gene ID: 81887, updated on 3-May-2020

Summary

Official Symbol
LAS1Lprovided by HGNC
Official Full Name
LAS1 like ribosome biogenesis factorprovided by HGNC
Primary source
HGNC:HGNC:25726
See related
Ensembl:ENSG00000001497 MIM:300964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WTS; Las1; Las1-like; dJ475B7.2
Expression
Ubiquitous expression in testis (RPKM 11.3), brain (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See LAS1L in Genome Data Viewer
Location:
Xq12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (65512582..65534806, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64732462..64754686, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene TLE family member 1 pseudogene 1 Neighboring gene AP1M2 pseudogene 1 Neighboring gene uncharacterized LOC107985679 Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene moesin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12525, FLJ30133, FLJ45274

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Las1 complex IEA
Inferred from Electronic Annotation
more info
 
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosomal biogenesis protein LAS1L
Names
protein LAS1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016369.1 RefSeqGene

    Range
    5001..27225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170649.1NP_001164120.1  ribosomal biogenesis protein LAS1L isoform 2

    See identical proteins and their annotated locations for NP_001164120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS55434.1
    UniProtKB/Swiss-Prot
    Q9Y4W2
    Related
    ENSP00000363940.5, ENST00000374807.9
    Conserved Domains (1) summary
    pfam04031
    Location:43187
    Las1; Las1-like
  2. NM_001170650.1NP_001164121.1  ribosomal biogenesis protein LAS1L isoform 3

    See identical proteins and their annotated locations for NP_001164121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS55433.1
    UniProtKB/Swiss-Prot
    Q9Y4W2
    Related
    ENSP00000363937.5, ENST00000374804.9
    Conserved Domains (1) summary
    pfam04031
    Location:43145
    Las1; Las1-like
  3. NM_001375328.1NP_001362257.1  ribosomal biogenesis protein LAS1L isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL050306
  4. NM_001375329.1NP_001362258.1  ribosomal biogenesis protein LAS1L isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL050306
  5. NM_001375330.1NP_001362259.1  ribosomal biogenesis protein LAS1L isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL050306
  6. NM_001375331.1NP_001362260.1  ribosomal biogenesis protein LAS1L isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL050306
  7. NM_001375332.1NP_001362261.1  ribosomal biogenesis protein LAS1L isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL050306
  8. NM_001375333.1NP_001362262.1  ribosomal biogenesis protein LAS1L isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL050306
  9. NM_001375334.1NP_001362263.1  ribosomal biogenesis protein LAS1L isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL050306
  10. NM_001375335.1NP_001362264.1  ribosomal biogenesis protein LAS1L isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL050306
  11. NM_001375336.1NP_001362265.1  ribosomal biogenesis protein LAS1L isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL050306
  12. NM_001375337.1NP_001362266.1  ribosomal biogenesis protein LAS1L isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL050306
  13. NM_031206.7NP_112483.1  ribosomal biogenesis protein LAS1L isoform 1

    See identical proteins and their annotated locations for NP_112483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF116730, DA619280
    Consensus CDS
    CCDS14381.1
    UniProtKB/Swiss-Prot
    Q9Y4W2
    Related
    ENSP00000363944.3, ENST00000374811.7
    Conserved Domains (1) summary
    pfam04031
    Location:43187
    Las1; Las1-like

RNA

  1. NR_164681.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL050306

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    65512582..65534806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029879.2XP_016885368.1  ribosomal biogenesis protein LAS1L isoform X9

  2. XM_011531045.2XP_011529347.1  ribosomal biogenesis protein LAS1L isoform X3

    Conserved Domains (1) summary
    pfam04031
    Location:43145
    Las1; Las1-like
  3. XM_005262306.4XP_005262363.1  ribosomal biogenesis protein LAS1L isoform X7

    Conserved Domains (1) summary
    pfam04031
    Location:43187
    Las1; Las1-like
  4. XM_011531046.2XP_011529348.1  ribosomal biogenesis protein LAS1L isoform X5

    Conserved Domains (1) summary
    pfam04031
    Location:43187
    Las1; Las1-like

RNA

  1. XR_001755730.2 RNA Sequence

  2. XR_001755733.2 RNA Sequence

  3. XR_430522.2 RNA Sequence

  4. XR_001755731.2 RNA Sequence

  5. XR_001755732.2 RNA Sequence

  6. XR_938412.2 RNA Sequence

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