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dhfr dihydrofolate reductase [ Danio rerio (zebrafish) ]

Gene ID: 81882, updated on 19-Jun-2024

Summary

Official Symbol
dhfrprovided by ZNC
Official Full Name
dihydrofolate reductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010406-5
See related
Ensembl:ENSDARG00000004251 AllianceGenome:ZFIN:ZDB-GENE-010406-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb595; zgc:86637
Summary
Enables dihydrofolate reductase activity. Acts upstream of or within folic acid metabolic process; heart contraction; and heart development. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior neural tube; hematopoietic system; immature eye; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human DHFR (dihydrofolate reductase) and DHFR2 (dihydrofolate reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See dhfr in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26138313..26145917)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25538160..25545764)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene beta-carotene 15, 15-dioxygenase 2, like Neighboring gene si:ch211-214j8.12 Neighboring gene ankyrin repeat domain 34Bb Neighboring gene family with sequence similarity 151 member B

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables dihydrofolate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dihydrofolate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dihydrofolate reductase
NP_571850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131775.1NP_571850.1  dihydrofolate reductase

    See identical proteins and their annotated locations for NP_571850.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071330
    UniProtKB/TrEMBL
    Q6IQS4
    Related
    ENSDARP00000014124.6, ENSDART00000010041.8
    Conserved Domains (1) summary
    cd00209
    Location:5186
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    26138313..26145917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)