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RAB1B RAB1B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 81876, updated on 22-Aug-2020

Summary

Official Symbol
RAB1Bprovided by HGNC
Official Full Name
RAB1B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:18370
See related
Ensembl:ENSG00000174903 MIM:612565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]
Expression
Ubiquitous expression in prostate (RPKM 64.5), fat (RPKM 64.0) and 25 other tissues See more
Orthologs

Genomic context

See RAB1B in Genome Data Viewer
Location:
11q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66268526..66277492)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66036056..66044963)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369352 Neighboring gene kinesin light chain 2 Neighboring gene uncharacterized LOC105369351 Neighboring gene uncharacterized LOC107984340 Neighboring gene cornichon family AMPA receptor auxiliary protein 2 Neighboring gene Yip1 interacting factor homolog A, membrane trafficking protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAB1B, member RAS oncogene family (RAB1B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Overexpression of TBC1D20, RAB1A, or RAB1B results in abnormal HIV-1 gp41 migration, suggesting that a precise regulation of the RAB1/TBC1D20 axis is necessary for proper HIV-1 gp41 processing PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of glycoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
virion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT virion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-1B
Names
small GTP-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030981.3NP_112243.1  ras-related protein Rab-1B

    See identical proteins and their annotated locations for NP_112243.1

    Status: VALIDATED

    Source sequence(s)
    AL136635, AP001107
    Consensus CDS
    CCDS31613.1
    UniProtKB/Swiss-Prot
    Q9H0U4
    Related
    ENSP00000310226.6, ENST00000311481.11
    Conserved Domains (1) summary
    cd01869
    Location:7172
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66268526..66277492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018378.1XP_016873867.1  ras-related protein Rab-1B isoform X1

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