BOP2 Ankyrin repeat family protein / BTB/POZ domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: BOP2
Gene description: Ankyrin repeat family protein / BTB/POZ domain-containing protein
Primary source: Araport:AT2G41370
Locus tag: AT2G41370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BLADE ON PETIOLE2; F13H10.8; F13H10_8
Summary: Encodes BOP2, a cytoplasmic and nuclear-localized NPR1 like protein with BTB/POZ domain and ankyrin repeats. Interacts with BOP1 and appears to be genetically redundant with BOP1.bop1/bop2 double mutants have longer leaves, often with leaflets on the petiole, asymmetric flowers with extra organs and no nectaries. Also defective in floral organ abscission. BOP1/2 promotes floral meristem fate and determinacy in a pathway targetting APETALA1 and AGAMOUS-LIKE24. PUCHI, BOP1 and BOP2 are redundantly required for expression of LFY and AP1. BOP2 is expressed in valve margin. Misexpression in stems causes short internodes and ectopic biosynthesis of lignin. BOP2 activity is antagonistic to BP (At4g08150) and PNY (At5g02030). BOP3 expression is restricted to pedicel axils by BP and PNY. BOP2 promotes KNAT6 (At1g23380) expression.
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Genomic context

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Location:: chromosome: 2

Exon count:: 2

Sequence:: Chromosome: 2; NC_003071.7 (17237727..17240609, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of Development.
Title: Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of Development.
LFY activity is fully dependent on BOP2 as well as on CUL3A and B to regulate target genes such as APETALA1 and to induce ectopic flower formation.
Title: LEAFY activity is post-transcriptionally regulated by BLADE ON PETIOLE2 and CULLIN3 in Arabidopsis.
This shows that BOP proteins act as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for ubiquitination and subsequent degradation.
Title: BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance.
HAN physically interacts with JAG, and directly stimulates the expression of JAG and BOP2 to regulate floral organ development
Title: HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis.
Only the reduction of both bop1 and bop2 expression affects resistance triggered by methyl jasmonate.
Title: The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate.
FYF controls floral senescence/abscission by repressing ethylene responses and regulating the expression of BOP2 and IDA in Arabidopsis.
Title: The MADS box gene, FOREVER YOUNG FLOWER, acts as a repressor controlling floral organ senescence and abscission in Arabidopsis.
BOP1/2 gain-of-function in stems promotes expression of the boundary gene KNOTTED1-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) and ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).
Title: BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1.
Data reveal an important supporting role for BOP1/2 in remodeling shoot architecture during the floral transition.
Title: Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24.
BOP1/BOP2 activity is required for multiple cell differentiation events in the proximal regions of inflorescence lateral organs.
Title: The BLADE-ON-PETIOLE genes are essential for abscission zone formation in Arabidopsis.
BOP1 and BOP2 act in cells adjacent to the lateral organ boundary to repress genes that confer meristem cell fate and induce genes that promote lateral organ fate and polarity.
Title: BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129700.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bract formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within floral meristem determinacy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within floral organ abscission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in floral organ abscission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within flower morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within induced systemic resistance, jasmonic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nectary development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within polarity specification of adaxial/abaxial axis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proximal/distal pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Ankyrin repeat family protein / BTB/POZ domain-containing protein

NP_181668.1

BLADE ON PETIOLE2 (BOP2); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein / BTB/POZ domain-containing protein (TAIR:AT3G57130.1); Has 6067 Blast hits to 4933 proteins in 392 species: Archae - 26; Bacteria - 465; Metazoa - 2734; Fungi - 296; Plants - 944; Viruses - 70; Other Eukaryotes - 1532 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

17237727..17240609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129700.3 → NP_181668.1 Ankyrin repeat family protein / BTB/POZ domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q84WN1, Q9ZVC2

UniProtKB/TrEMBL

A0A5S9X646

Conserved Domains (6) summary

pfam11900
Location:204 → 260

DUF3420; Domain of unknown function (DUF3420)

smart00225
Location:27 → 167

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:262 → 358

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00651
Location:16 → 121

BTB; BTB/POZ domain

pfam12796
Location:262 → 348

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:287 → 315

ANK; ANK repeat [structural motif]