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ZNF239 zinc finger protein 239 [ Homo sapiens (human) ]

Gene ID: 8187, updated on 13-Mar-2020

Summary

Official Symbol
ZNF239provided by HGNC
Official Full Name
zinc finger protein 239provided by HGNC
Primary source
HGNC:HGNC:13031
See related
Ensembl:ENSG00000196793 MIM:601069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOK2; HOK-2
Summary
MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 1.5), prostate (RPKM 1.2) and 22 other tissues See more
Orthologs

Genomic context

See ZNF239 in Genome Data Viewer
Location:
10q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (43554516..43574619, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (44051792..44070066, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379857 Neighboring gene zinc finger protein 12 pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2 pseudogene Neighboring gene CAP1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 239
Names
zinc finger protein (C2H2) homologous to mouse MOK-2
zinc finger protein HOK-2
zinc finger protein MOK-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099282.2NP_001092752.1  zinc finger protein 239 isoform a

    See identical proteins and their annotated locations for NP_001092752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AL450326, BC026030
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Related
    ENSP00000363569.1, ENST00000374446.6
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001099283.1NP_001092753.1  zinc finger protein 239 isoform a

    See identical proteins and their annotated locations for NP_001092753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AL450326, BC026030, DA686973
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Related
    ENSP00000443907.1, ENST00000535642.5
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001099284.1NP_001092754.1  zinc finger protein 239 isoform a

    See identical proteins and their annotated locations for NP_001092754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AL450326, BC026030, DA937379
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Related
    ENSP00000398202.1, ENST00000426961.1
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001324347.2NP_001311276.1  zinc finger protein 239 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6-9, encodes isoform a.
    Source sequence(s)
    AL450326
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001324348.2NP_001311277.1  zinc finger protein 239 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5 and 7-9, encodes isoform a.
    Source sequence(s)
    AL450326
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001324349.2NP_001311278.1  zinc finger protein 239 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1-6 and 8-9, encodes isoform a.
    Source sequence(s)
    AL450326
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001324350.2NP_001311279.1  zinc finger protein 239 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1-7 and 9, encodes isoform a.
    Source sequence(s)
    AL450326
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001324351.2NP_001311280.1  zinc finger protein 239 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1-8, encodes isoform a.
    Source sequence(s)
    AL450326, DN994387
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001324352.2NP_001311281.1  zinc finger protein 239 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL450326, DA597035
    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001324353.2NP_001311282.1  zinc finger protein 239 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL450326, CK820210
  11. NM_005674.2NP_005665.2  zinc finger protein 239 isoform a

    See identical proteins and their annotated locations for NP_005665.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-9 all encode the same isoform (a).
    Source sequence(s)
    AL450326, BC026030, X82125
    Consensus CDS
    CCDS41502.1
    UniProtKB/Swiss-Prot
    Q16600
    Related
    ENSP00000307774.6, ENST00000306006.10
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    43554516..43574619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540234.2XP_011538536.1  zinc finger protein 239 isoform X2

    See identical proteins and their annotated locations for XP_011538536.1

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011540235.2XP_011538537.1  zinc finger protein 239 isoform X2

    See identical proteins and their annotated locations for XP_011538537.1

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017016740.1XP_016872229.1  zinc finger protein 239 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011540236.2XP_011538538.1  zinc finger protein 239 isoform X2

    See identical proteins and their annotated locations for XP_011538538.1

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006718003.3XP_006718066.1  zinc finger protein 239 isoform X4

    See identical proteins and their annotated locations for XP_006718066.1

    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011540232.3XP_011538534.1  zinc finger protein 239 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:337537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:521541
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:519541
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:533558
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011540237.2XP_011538539.1  zinc finger protein 239 isoform X2

    See identical proteins and their annotated locations for XP_011538539.1

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  8. XM_005271832.2XP_005271889.1  zinc finger protein 239 isoform X4

    See identical proteins and their annotated locations for XP_005271889.1

    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006718001.2XP_006718064.1  zinc finger protein 239 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:235435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:417439
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431456
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011540238.2XP_011538540.1  zinc finger protein 239 isoform X4

    See identical proteins and their annotated locations for XP_011538540.1

    UniProtKB/Swiss-Prot
    Q16600
    Conserved Domains (4) summary
    COG5048
    Location:193393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
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