CYP98A3 cytochrome P450, family 98, subfamily A, polypeptide 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYP98A3
Official Full Name: cytochrome P450, family 98, subfamily A, polypeptide 3
Primary source: TAIR:AT2G40890
Locus tag: AT2G40890
See related: Araport:AT2G40890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cytochrome P450; family 98; polypeptide 3; REDUCED EPIDERMAL FLUORESCENCE 8; REF8; subfamily A; T20B5.9; T20B5_9
Summary: encodes coumarate 3-hydroxylase (C3H), a P450-dependent monooxygenase. Involved in lignin biosynthesis and flavonoid biosynthesis. Also affects the biosynthesis of coumarins such as scopoletin and scopolin as a branching-out-pathway from the phenylpropanoid acid level.
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Genomic context

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See CYP98A3 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (17058053..17060652, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ref8 mutant accumulates higher levels of salicylic acid than the wild type, but depletion of this compound in ref8 did not relieve the mutant's growth defects.[Ref8]
Title: Chemically induced conditional rescue of the reduced epidermal fluorescence8 mutant of Arabidopsis reveals rapid restoration of growth and selective turnover of secondary metabolite pools.
CYP73A5 and CYP98A3, the two Arabidopsis cytochrome P450s (P450s) catalyzing para- and meta-hydroxylations of the phenolic ring of monolignols were found to colocalize in the endoplasmic reticulum (ER) and to form homo- and heteromers.
Title: Protein-protein and protein-membrane associations in the lignin pathway.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_180006.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables p-coumarate 3-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables p-coumarate 3-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within coumarin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flavonoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phenylpropanoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: cytochrome P450, family 98, subfamily A, polypeptide 3

NP_850337.1

cytochrome P450, family 98, subfamily A, polypeptide 3 (CYP98A3); FUNCTIONS IN: monooxygenase activity, p-coumarate 3-hydroxylase activity; INVOLVED IN: coumarin biosynthetic process, lignin biosynthetic process, phenylpropanoid biosynthetic process, flavonoid biosynthetic process; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, microsome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 9 (TAIR:AT1G74550.1); Has 33899 Blast hits to 33682 proteins in 1752 species: Archae - 48; Bacteria - 3997; Metazoa - 11870; Fungi - 7164; Plants - 9566; Viruses - 3; Other Eukaryotes - 1251 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

17058053..17060652 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180006.2 → NP_850337.1 cytochrome P450, family 98, subfamily A, polypeptide 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22203, Q0WWH4, Q940C7

UniProtKB/TrEMBL

A0A178VTT8, A0A5S9X5V5

Conserved Domains (1) summary

cd20656
Location:58 → 490

CYP98; cytochrome P450 family 98