Format

Send to:

Choose Destination

TMEM14B transmembrane protein 14B [ Homo sapiens (human) ]

Gene ID: 81853, updated on 25-Nov-2021

Summary

Official Symbol
TMEM14Bprovided by HGNC
Official Full Name
transmembrane protein 14Bprovided by HGNC
Primary source
HGNC:HGNC:21384
See related
Ensembl:ENSG00000137210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 31.1), bone marrow (RPKM 27.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM14B in Genome Data Viewer
Location:
6p24.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (10747759..10759774)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (10747992..10760007)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 52 Neighboring gene PAK1 interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 12108 Neighboring gene transmembrane protein 14C Neighboring gene RNA, 5S ribosomal pseudogene 203 Neighboring gene male germ cell associated kinase Neighboring gene glial cells missing transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1223, FLJ60468

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127711.3NP_001121183.1  transmembrane protein 14B isoform b

    See identical proteins and their annotated locations for NP_001121183.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BC071660, BP249229
    Consensus CDS
    CCDS47372.1
    UniProtKB/Swiss-Prot
    Q9NUH8
    Related
    ENSP00000368845.3, ENST00000379530.7
    Conserved Domains (1) summary
    pfam03647
    Location:1369
    Tmemb_14; Transmembrane proteins 14C
  2. NM_001286484.2NP_001273413.1  transmembrane protein 14B isoform c

    See identical proteins and their annotated locations for NP_001273413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, resulting in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK311340, BC071660, BG288654
    Consensus CDS
    CCDS75395.1
    UniProtKB/Swiss-Prot
    Q9NUH8
    UniProtKB/TrEMBL
    A0A087WU83
    Related
    ENSP00000478448.1, ENST00000612333.4
    Conserved Domains (1) summary
    pfam03647
    Location:2492
    Tmemb_14; Transmembrane proteins 14C
  3. NM_001286488.2NP_001273417.1  transmembrane protein 14B isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AI343263, AK311340, AL024498, BG432075, BQ045109, BQ056988
    Consensus CDS
    CCDS75396.1
    UniProtKB/TrEMBL
    C9JCY4
    Related
    ENSP00000420658.1, ENST00000467317.5
    Conserved Domains (2) summary
    pfam03647
    Location:13103
    Tmemb_14; Transmembrane proteins 14C
    pfam13900
    Location:104151
    GVQW; Putative domain of unknown function
  4. NM_001286489.2NP_001273418.1  transmembrane protein 14B isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region and contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AI343263, AK311340, AL024498, BQ045109, BQ056988
    Consensus CDS
    CCDS75397.1
    UniProtKB/TrEMBL
    C9JQS0
    Related
    ENSP00000420172.1, ENST00000481240.5
    Conserved Domains (2) summary
    pfam03647
    Location:1369
    Tmemb_14; Transmembrane proteins 14C
    pfam13900
    Location:70117
    GVQW; Putative domain of unknown function
  5. NM_030969.5NP_112231.3  transmembrane protein 14B isoform a

    See identical proteins and their annotated locations for NP_112231.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK311340, BC071660
    Consensus CDS
    CCDS4515.1
    UniProtKB/Swiss-Prot
    Q9NUH8
    UniProtKB/TrEMBL
    A0A024QZV7
    Related
    ENSP00000368858.5, ENST00000379542.10
    Conserved Domains (1) summary
    pfam03647
    Location:13103
    Tmemb_14; Transmembrane proteins 14C

RNA

  1. NR_104454.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK311340, BC071660, BU954633
    Related
    ENST00000473276.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    10747759..10759774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center