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KRTAP1-1 keratin associated protein 1-1 [ Homo sapiens (human) ]

Gene ID: 81851, updated on 13-May-2022

Summary

Official Symbol
KRTAP1-1provided by HGNC
Official Full Name
keratin associated protein 1-1provided by HGNC
Primary source
HGNC:HGNC:16772
See related
Ensembl:ENSG00000188581 MIM:608819; AllianceGenome:HGNC:16772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1
Summary
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See KRTAP1-1 in Genome Data Viewer
Location:
17q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41040541..41041450, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41905025..41905934, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39196793..39197702, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 1-4 Neighboring gene keratin associated protein 1-3 Neighboring gene keratin associated protein 2-1 Neighboring gene keratin associated protein 2-2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 1-1
Names
high sulfur keratin-associated protein 1.1
keratin associated protein 1.7
keratin associated protein 1A
keratin-associated protein 1.1
keratin-associated protein 1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050762.1 RefSeqGene

    Range
    5012..5921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030967.3NP_112229.1  keratin-associated protein 1-1

    See identical proteins and their annotated locations for NP_112229.1

    Status: REVIEWED

    Source sequence(s)
    AB052934, AC007455
    Consensus CDS
    CCDS42324.1
    UniProtKB/Swiss-Prot
    Q07627
    Related
    ENSP00000305975.4, ENST00000306271.5
    Conserved Domains (2) summary
    pfam01500
    Location:1177
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:2484
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41040541..41041450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    189934..190843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41905025..41905934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)