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NIP2;1 NOD26-like intrinsic protein 2;1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818002, updated on 18-Sep-2024
Official Symbol
NIP2;1
Official Full Name
NOD26-like intrinsic protein 2;1
Primary source
TAIR:AT2G34390
Locus tag
AT2G34390
See related
Araport:AT2G34390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F13P17.30; NLM4; NOD26-like intrinsic protein 2;1; NOD26-LIKE MIP 4
Summary
aquaporin NIP2.1
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See NIP2;1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (14514487..14515988, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene MATE efflux family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Putative adipose-regulatory protein (Seipin) Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene O-acetyltransferase family protein Neighboring gene ncRNA Neighboring gene photosystem II light harvesting complex protein B1B2

Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis. Beamer ZG, et al. Plant Physiol, 2021 Dec 4. PMID 34890456, Free PMC Article
  2. Surviving hypoxia: aquaporin-like protein NIP2;1 mediates lactic acid transport. Ponnu J. Plant Physiol, 2021 Aug 3. PMID 34618117, Free PMC Article
  3. Arabidopsis NIP2;1, a major intrinsic protein transporter of lactic acid induced by anoxic stress. Choi WG, et al. J Biol Chem, 2007 Aug 17. PMID 17584741
  4. Aquaporin NIP2;1 is mainly localized to the ER membrane and shows root-specific accumulation in Arabidopsis thaliana. Mizutani M, et al. Plant Cell Physiol, 2006 Oct. PMID 16954136
  5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surviving hypoxia: aquaporin-like protein NIP2;1 mediates lactic acid transport.
    Title: Surviving hypoxia: aquaporin-like protein NIP2;1 mediates lactic acid transport.
  2. AtNIP2;1 is an anaerobic-induced gene that encodes a lactic acid transporter and may play a role in adaptation to lactic fermentation under anaerobic stress.
    Title: Arabidopsis NIP2;1, a major intrinsic protein transporter of lactic acid induced by anoxic stress.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description
NM_001336511.1
NM_001336512.1
NM_001336513.1
NM_128991.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables lactate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lactate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
Preferred Names
NOD26-like intrinsic protein 2;1
NP_180986.1
  • NOD26-like intrinsic protein 2;1 (NIP2;1); CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like intrinsic protein 1;2 (TAIR:AT4G18910.1); Has 10129 Blast hits to 10099 proteins in 2148 species: Archae - 82; Bacteria - 5107; Metazoa - 1358; Fungi - 399; Plants - 2013; Viruses - 4; Other Eukaryotes - 1166 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14514487..14515988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128991.5 → NP_180986.1  NOD26-like intrinsic protein 2;1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180986.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64706, Q1ECK8, Q8W037
    UniProtKB/TrEMBL
    A0A178VT16, A0A5S9X3T6
    Conserved Domains (1) summary
    cl00200
    Location:6 → 283
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  2. NM_001336511.1 → NP_001324019.1  NOD26-like intrinsic protein 2;1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AYX5, A0A5S9X3T6

  3. NM_001336512.1 → NP_001324020.1  NOD26-like intrinsic protein 2;1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AYY0

  4. NM_001336513.1 → NP_001324018.1  NOD26-like intrinsic protein 2;1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AYR6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8W037.2

Gene LinkOut

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