Format

Send to:

Choose Destination

SLCO5A1 solute carrier organic anion transporter family member 5A1 [ Homo sapiens (human) ]

Gene ID: 81796, updated on 24-Nov-2020

Summary

Official Symbol
SLCO5A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 5A1provided by HGNC
Primary source
HGNC:HGNC:19046
See related
Ensembl:ENSG00000137571 MIM:613543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15
Summary
This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in small intestine (RPKM 68.6), ovary (RPKM 66.6) and 25 other tissues See more
Orthologs

Genomic context

See SLCO5A1 in Genome Data Viewer
Location:
8q13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (69667046..69835064, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70584110..70747299, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1603 Neighboring gene sulfatase 1 Neighboring gene uncharacterized LOC105375889 Neighboring gene RN7SK pseudogene 29 Neighboring gene thioredoxin related transmembrane protein 1 pseudogene Neighboring gene uncharacterized LOC101929759 Neighboring gene BAG cochaperone 4 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 675, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and the control of HIV-1 in humans.
GeneReviews: Not available
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier organic anion transporter family member 5A1
Names
organic anion transporter polypeptide-related protein 4
solute carrier family 21 (organic anion transporter), member 15
solute carrier family 21 member 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146008.2NP_001139480.1  solute carrier organic anion transporter family member 5A1 isoform 2

    See identical proteins and their annotated locations for NP_001139480.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, AK022760, CA449383
    Consensus CDS
    CCDS55243.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000434422.1, ENST00000524945.5
    Conserved Domains (3) summary
    cd06174
    Location:131531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129674
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_001146009.1NP_001139481.1  solute carrier organic anion transporter family member 5A1 isoform 3

    See identical proteins and their annotated locations for NP_001139481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, BC139755, CA449383
    Consensus CDS
    CCDS55242.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000431611.1, ENST00000530307.1
    Conserved Domains (3) summary
    cd06174
    Location:131368
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:496550
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129679
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. NM_030958.3NP_112220.2  solute carrier organic anion transporter family member 5A1 isoform 1

    See identical proteins and their annotated locations for NP_112220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC091047, AK096879, BC137424, CA449383
    Consensus CDS
    CCDS6205.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    UniProtKB/TrEMBL
    B3KUC7
    Related
    ENSP00000260126.3, ENST00000260126.9
    Conserved Domains (3) summary
    cd06174
    Location:131531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129734
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    69667046..69835064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251313.2XP_005251370.1  solute carrier organic anion transporter family member 5A1 isoform X1

    See identical proteins and their annotated locations for XP_005251370.1

    UniProtKB/Swiss-Prot
    Q9H2Y9
    Conserved Domains (3) summary
    cd06174
    Location:131368
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:496550
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129679
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. XM_017013883.1XP_016869372.1  solute carrier organic anion transporter family member 5A1 isoform X2

    UniProtKB/Swiss-Prot
    Q9H2Y9
    Conserved Domains (3) summary
    cd06174
    Location:131531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129674
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  3. XM_017013885.1XP_016869374.1  solute carrier organic anion transporter family member 5A1 isoform X4

  4. XM_017013884.1XP_016869373.1  solute carrier organic anion transporter family member 5A1 isoform X3

  5. XM_017013886.1XP_016869375.1  solute carrier organic anion transporter family member 5A1 isoform X5

RNA

  1. XR_928814.1 RNA Sequence

  2. XR_428341.2 RNA Sequence

Support Center