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TLR10 toll like receptor 10 [ Homo sapiens (human) ]

Gene ID: 81793, updated on 8-Jul-2021

Summary

Official Symbol
TLR10provided by HGNC
Official Full Name
toll like receptor 10provided by HGNC
Primary source
HGNC:HGNC:15634
See related
Ensembl:ENSG00000174123 MIM:606270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD290
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Expression
Biased expression in lymph node (RPKM 20.4), spleen (RPKM 11.7) and 3 other tissues See more
Orthologs
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Genomic context

See TLR10 in Genome Data Viewer
Location:
4p14
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (38772238..38782990, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38773859..38784611, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374412 Neighboring gene RNA, 5S ribosomal pseudogene 158 Neighboring gene Sharpr-MPRA regulatory region 13104 Neighboring gene toll like receptor 1 Neighboring gene toll like receptor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Identification of genetic loci associated with Helicobacter pylori serologic status.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104967, MGC126398, MGC126399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 10 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
toll-like receptor 10
NP_001017388.1
NP_001182035.1
NP_001182036.1
NP_001182037.1
NP_112218.2
XP_011512062.1
XP_011512063.1
XP_011512064.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017388.3NP_001017388.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001017388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AC118137, AY358300, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000354459.2, ENST00000361424.6
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
  2. NM_001195106.2NP_001182035.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001182035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one exon in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AC118137, AW504309, AY358300, DA213264, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000478206.1, ENST00000613579.4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
  3. NM_001195107.2NP_001182036.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001182036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks one exon in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AC118137, AF296673, AY358300, DA312129, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000478985.1, ENST00000622002.4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
  4. NM_001195108.2NP_001182037.1  toll-like receptor 10 isoform b

    See identical proteins and their annotated locations for NP_001182037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and uses a different splice site which results in part of the 5' coding region being absent, compared to variant 1. The resulting predicted protein (isoform b) has a shorter N-terminus and is missing a potential signal peptide when it is compared to isoform a.
    Source sequence(s)
    AC118137, AF296673, AY358300, BP383038, DA643313
    UniProtKB/Swiss-Prot
    Q9BXR5
    Conserved Domains (6) summary
    smart00082
    Location:508560
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:619761
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:334441
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:3659
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:336359
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:58115
    LRR_8; Leucine rich repeat
  5. NM_030956.4NP_112218.2  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_112218.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AC118137, AF296673, AY358300, DA643313, DB226380
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000308925.4, ENST00000308973.9
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    38772238..38782990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513760.2XP_011512062.1  toll-like receptor 10 isoform X1

    See identical proteins and their annotated locations for XP_011512062.1

    Conserved Domains (6) summary
    smart00082
    Location:508560
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:619761
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:334441
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:3659
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:336359
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:58115
    LRR_8; Leucine rich repeat
  2. XM_011513761.2XP_011512063.1  toll-like receptor 10 isoform X2

    See identical proteins and their annotated locations for XP_011512063.1

    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
  3. XM_011513762.2XP_011512064.1  toll-like receptor 10 isoform X2

    See identical proteins and their annotated locations for XP_011512064.1

    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:289522
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
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