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TIGD6 tigger transposable element derived 6 [ Homo sapiens (human) ]

Gene ID: 81789, updated on 1-Jun-2020

Summary

Official Symbol
TIGD6provided by HGNC
Official Full Name
tigger transposable element derived 6provided by HGNC
Primary source
HGNC:HGNC:18332
See related
Ensembl:ENSG00000164296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in prostate (RPKM 1.9), testis (RPKM 1.8) and 25 other tissues See more
Orthologs

Genomic context

See TIGD6 in Genome Data Viewer
Location:
5q32
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149993118..150000654, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149372686..149380730, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6A Neighboring gene MFF pseudogene 2 Neighboring gene solute carrier family 26 member 2 Neighboring gene HMG-box containing 3 Neighboring gene ribosomal protein S20 pseudogene 4 Neighboring gene enhancer in exon 7 of CSF1R Neighboring gene colony stimulating factor 1 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761E2110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tigger transposable element-derived protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243253.2NP_001230182.1  tigger transposable element-derived protein 6

    See identical proteins and their annotated locations for NP_001230182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011406, AL136539, BC033641
    Consensus CDS
    CCDS4301.1
    UniProtKB/Swiss-Prot
    Q17RP2
    Related
    ENSP00000425318.2, ENST00000515406.2
    Conserved Domains (4) summary
    COG2963
    Location:557
    InsE; Transposase and inactivated derivatives [Mobilome: prophages, transposons]
    pfam03221
    Location:75134
    HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
    cl21459
    Location:754
    HTH; Helix-turn-helix domains
    cl21549
    Location:207372
    rve; Integrase core domain
  2. NM_030953.4NP_112215.1  tigger transposable element-derived protein 6

    See identical proteins and their annotated locations for NP_112215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC011406, AK096325, AL136539
    Consensus CDS
    CCDS4301.1
    UniProtKB/Swiss-Prot
    Q17RP2
    Related
    ENSP00000296736.3, ENST00000296736.4
    Conserved Domains (4) summary
    COG2963
    Location:557
    InsE; Transposase and inactivated derivatives [Mobilome: prophages, transposons]
    pfam03221
    Location:75134
    HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
    cl21459
    Location:754
    HTH; Helix-turn-helix domains
    cl21549
    Location:207372
    rve; Integrase core domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149993118..150000654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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