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TRIM7 tripartite motif containing 7 [ Homo sapiens (human) ]

Gene ID: 81786, updated on 23-Nov-2021

Summary

Official Symbol
TRIM7provided by HGNC
Official Full Name
tripartite motif containing 7provided by HGNC
Primary source
HGNC:HGNC:16278
See related
Ensembl:ENSG00000146054 MIM:609315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNIP; RNF90
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in skin (RPKM 5.6), esophagus (RPKM 2.8) and 8 other tissues See more
Orthologs
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Genomic context

See TRIM7 in Genome Data Viewer
Location:
5q35.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (181193924..181218332, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180620924..180632196, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon TGG) 3-1 Neighboring gene long intergenic non-protein coding RNA 1962 Neighboring gene tRNA-Thr (anticodon TGT) 6-1 Neighboring gene TRIM7 antisense RNA 2 Neighboring gene TRIM7 antisense RNA 1 Neighboring gene tRNA-Ala (anticodon TGC) 3-1 Neighboring gene tRNA-Lys (anticodon CTT) 2-2 Neighboring gene tRNA-Val (anticodon AAC) 1-4 Neighboring gene tRNA-Lys (anticodon CTT) 2-3 Neighboring gene tRNA-Val (anticodon CAC) 1-5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 7 (TRIM7) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM7
Names
RING finger protein 90
glycogenin-interacting protein
tripartite motif protein TRIM7
NP_203128.1
NP_976038.1
NP_976039.1
NP_976040.1
NP_976041.1
NP_976042.1
XP_016865392.1
XP_016865393.1
XP_024301992.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029535.1 RefSeqGene

    Range
    4982..16254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033342.4NP_203128.1  E3 ubiquitin-protein ligase TRIM7 isoform 4

    See identical proteins and their annotated locations for NP_203128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region, resulting in an early stop codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF220032, BC080553
    Consensus CDS
    CCDS4464.1
    UniProtKB/Swiss-Prot
    Q9C029
    Related
    ENSP00000334666.5, ENST00000334421.5
    Conserved Domains (3) summary
    cd00021
    Location:130166
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:2981
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:159211
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_203293.3NP_976038.1  E3 ubiquitin-protein ligase TRIM7 isoform 1

    See identical proteins and their annotated locations for NP_976038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as GNIP1) encodes the longest isoform (1).
    Source sequence(s)
    AF220032, BC132863, BM825056, BQ000256
    Consensus CDS
    CCDS4462.1
    UniProtKB/Swiss-Prot
    Q9C029
    Related
    ENSP00000274773.7, ENST00000274773.12
    Conserved Domains (4) summary
    cd00021
    Location:130166
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd13740
    Location:343511
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
    pfam01442
    Location:151276
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cd16592
    Location:2682
    RING-HC_TRIM7_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 7 (TRIM7) and similar proteins
  3. NM_203294.2NP_976039.1  E3 ubiquitin-protein ligase TRIM7 isoform 3

    See identical proteins and their annotated locations for NP_976039.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as GNIP2b) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF396652, BM825056, BQ000256
    Consensus CDS
    CCDS4463.1
    UniProtKB/Swiss-Prot
    Q9C029
    Conserved Domains (1) summary
    cd13740
    Location:135303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
  4. NM_203295.2NP_976040.1  E3 ubiquitin-protein ligase TRIM7 isoform 3

    See identical proteins and their annotated locations for NP_976040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as GNIP2a) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF396652, AF396653, BM825056, BQ000256
    Consensus CDS
    CCDS4463.1
    UniProtKB/Swiss-Prot
    Q9C029
    Related
    ENSP00000391458.2, ENST00000422067.2
    Conserved Domains (1) summary
    cd13740
    Location:135303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
  5. NM_203296.2NP_976041.1  E3 ubiquitin-protein ligase TRIM7 isoform 3

    See identical proteins and their annotated locations for NP_976041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as GNIP2c) differs in the 5' UTR and the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008443, AF396652, AF396654, BM825056, BQ000256
    Consensus CDS
    CCDS4463.1
    UniProtKB/Swiss-Prot
    Q9C029
    Related
    ENSP00000376991.1, ENST00000393315.5
    Conserved Domains (1) summary
    cd13740
    Location:135303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
  6. NM_203297.2NP_976042.1  E3 ubiquitin-protein ligase TRIM7 isoform 2

    See identical proteins and their annotated locations for NP_976042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as GNIP3) differs in the 5' UTR and the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008443, AF396655, BM825056, BQ000256
    Consensus CDS
    CCDS43414.1
    UniProtKB/Swiss-Prot
    Q9C029
    Related
    ENSP00000376994.3, ENST00000393319.7
    Conserved Domains (1) summary
    cd13740
    Location:161329
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    181193924..181218332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446224.1XP_024301992.1  E3 ubiquitin-protein ligase TRIM7 isoform X1

    Conserved Domains (4) summary
    cd00021
    Location:130166
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd13740
    Location:343511
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
    pfam01442
    Location:151276
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cd16592
    Location:2682
    RING-HC_TRIM7_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 7 (TRIM7) and similar proteins
  2. XM_017009903.1XP_016865392.1  E3 ubiquitin-protein ligase TRIM7 isoform X2

    UniProtKB/Swiss-Prot
    Q9C029
    Conserved Domains (1) summary
    cd13740
    Location:135303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
  3. XM_017009904.2XP_016865393.1  E3 ubiquitin-protein ligase TRIM7 isoform X3

    UniProtKB/Swiss-Prot
    Q9C029
    Conserved Domains (3) summary
    cd00021
    Location:130166
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:2981
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl21478
    Location:159211
    ATP-synt_B; ATP synthase B/B' CF(0)
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