GLR3.5 glutamate receptor 3.5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GLR3.5
Official Full Name: glutamate receptor 3.5
Primary source: TAIR:AT2G32390
Locus tag: AT2G32390
See related: Araport:AT2G32390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGLR3.5; GLR6; glutamate receptor 3.5; glutamate receptor 3.5; T32F6.9; T32F6_9
Summary: Encodes a ionotropic glutamate receptor ortholog, a member of a putative ligand-gated ion channel subunit family
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Genomic context

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See GLR3.5 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (13748280..13752281, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methionine synthase 1 provides methionine for activation of the GLR3.5 Ca2+ channel and regulation of germination in Arabidopsis.
Title: Methionine synthase 1 provides methionine for activation of the GLR3.5 Ca2+ channel and regulation of germination in Arabidopsis.
Our data indicate that GLR3.1/3.5 constitute L-Met-activated Ca(2+) channels responsible for maintaining basal [Ca(2+)]cyt, play a pivotal role in plant growth, and act upstream of ROS, thereby regulating stomatal aperture
Title: L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement.
GLR3.3 and GLR3.6 function as on switches for the propagation of wound-induced potentials beyond the wounded leaf, while GLR3.5 functions as an off switch that prevents the propagation of wound-induced electrical potentials to distal, non-neighbor leaves.
Title: New roles for the GLUTAMATE RECEPTOR-LIKE 3.3, 3.5, and 3.6 genes as on/off switches of wound-induced systemic electrical signals.
splicing variant targets the inner mitochondrial membrane and affects its morphology
Title: Alternative splicing-mediated targeting of the Arabidopsis GLUTAMATE RECEPTOR3.5 to mitochondria affects organelle morphology.

Submit: New GeneRIF Correction

General gene information

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NM_001036387.2

Supported by ESTs:

NM_001336393.1

Supported by ESTs:

NM_128798.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to light stimulus	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within seed germination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutamate receptor 3.5

NP_001031464.1

glutamate receptor 3.5 (GLR3.5); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Glutamate receptor-related (InterPro:IPR015683), Extracellular ligand-binding receptor (InterPro:IPR001828), GPCR, family 3 (InterPro:IPR000337), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.4 (TAIR:AT1G05200.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001318335.1

glutamate receptor 3.5 (GLR3.5); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), GPCR, family 3, gamma-aminobutyric acid receptor, type B (InterPro:IPR002455), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.4 (TAIR:AT1G05200.2).

NP_565743.1

glutamate receptor 3.5 (GLR3.5); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Glutamate receptor-related (InterPro:IPR015683), Extracellular ligand-binding receptor (InterPro:IPR001828), GPCR, family 3 (InterPro:IPR000337), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.4 (TAIR:AT1G05200.2); Has 5516 Blast hits to 5369 proteins in 333 species: Archae - 14; Bacteria - 348; Metazoa - 4290; Fungi - 0; Plants - 640; Viruses - 0; Other Eukaryotes - 224 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

13748280..13752281 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001336391.1 → NP_001324013.1 glutamate receptor 3.5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4ITQ1, Q9SW97, Q9ZV67

UniProtKB/TrEMBL

Q6RKN4
NM_001336390.1 → NP_001324012.1 glutamate receptor 3.5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

F4ITQ0
NM_001336389.1 → NP_001318335.1 glutamate receptor 3.5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

F4ITQ0
NM_001336392.1 → NP_001324010.1 glutamate receptor 3.5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AYW8
NM_001036387.2 → NP_001031464.1 glutamate receptor 3.5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031464.1

Status: REVIEWED

UniProtKB/TrEMBL

F4ITQ2, Q6RKN4

Conserved Domains (5) summary

cd06366
Location:1 → 340

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

COG0834
Location:398 → 511

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13686
Location:383 → 726

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

pfam00060
Location:506 → 758

Lig_chan; Ligand-gated ion channel

pfam01094
Location:1 → 322

ANF_receptor; Receptor family ligand binding region
NM_128798.1 → NP_565743.1 glutamate receptor 3.5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565743.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6RKN4

Conserved Domains (5) summary

cd06366
Location:49 → 384

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

COG0834
Location:442 → 555

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13686
Location:427 → 770

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

pfam00060
Location:550 → 802

Lig_chan; Ligand-gated ion channel

pfam01094
Location:49 → 366

ANF_receptor; Receptor family ligand binding region
NM_001336393.1 → NP_001324011.1 glutamate receptor 3.5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AYR0