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Grk1 G protein-coupled receptor kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81760, updated on 10-Oct-2019

Summary

Official Symbol
Grk1provided by RGD
Official Full Name
G protein-coupled receptor kinase 1provided by RGD
Primary source
RGD:619712
See related
Ensembl:ENSRNOG00000018430
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rhok
Summary
catalyzes the phosphorylation of rhodopsin to form phosphorhodopsin; plays a role in phototransduction [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 4.0), Brain (RPKM 2.6) and 4 other tissues See more
Orthologs

Genomic context

See Grk1 in Genome Data Viewer
Location:
16q12.5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81153489..81165442)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (80641991..80657693)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-1 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Phototransduction, organism-specific biosystem (from KEGG)
    Phototransduction, organism-specific biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
  • Phototransduction, conserved biosystem (from KEGG)
    Phototransduction, conserved biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
rhodopsin kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
rhodopsin kinase activity IEA
Inferred from Electronic Annotation
more info
 
rhodopsin kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
rhodopsin kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
photoreceptor cell morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
post-embryonic retina morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of rhodopsin mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of rhodopsin mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of rhodopsin mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
rhodopsin kinase GRK1
Names
G protein-coupled receptpr kinase 1
RK
rhodopsin kinase
NP_112358.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031096.1NP_112358.1  rhodopsin kinase GRK1

    See identical proteins and their annotated locations for NP_112358.1

    Status: PROVISIONAL

    Source sequence(s)
    U63971
    UniProtKB/Swiss-Prot
    Q63651
    Related
    ENSRNOP00000024999.2, ENSRNOT00000024999.4
    Conserved Domains (3) summary
    smart00220
    Location:194443
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05608
    Location:188475
    STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
    cl02565
    Location:42179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    81153489..81165442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    73931302..73943259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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