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Rab1a RAB1A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 81754, updated on 12-Aug-2018

Summary

Official Symbol
Rab1aprovided by RGD
Official Full Name
RAB1A, member RAS oncogene familyprovided by RGD
Primary source
RGD:619736
See related
Ensembl:ENSRNOG00000004992
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rab1; Rab1r; Ac2-048
Summary
may have GTPase activity; may regulate intracellular protein transport from the endoplasmic reticulum to the Golgi apparatus [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 1111.0), Liver (RPKM 914.2) and 9 other tissues See more
Orthologs

Genomic context

See Rab1a in Genome Data Viewer
Location:
14q22
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104475082..104500176)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (104208420..104235377)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27-like Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene centrosomal protein 68 Neighboring gene solute carrier family 1 member 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab protein signal transduction IC
Inferred by Curator
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
 
autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
cargo loading into COPII-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT cilium assembly ISO
Inferred from Sequence Orthology
more info
 
defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
NOT establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
growth hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanosome transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
virion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
melanosome ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
presynapse EXP
Inferred from Experiment
more info
PubMed 
presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-1A
Names
RAB1, member RAS oncogene family

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031090.2NP_112352.2  ras-related protein Rab-1A

    See identical proteins and their annotated locations for NP_112352.2

    Status: PROVISIONAL

    Source sequence(s)
    BC066662
    UniProtKB/Swiss-Prot
    Q6NYB7
    Related
    ENSRNOP00000073493.1, ENSRNOT00000084481.1
    Conserved Domains (1) summary
    cd01869
    Location:10175
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    104475082..104500176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    93445267..93470406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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