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Pth2r parathyroid hormone 2 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 81753, updated on 17-Nov-2020

Summary

Official Symbol
Pth2rprovided by RGD
Official Full Name
parathyroid hormone 2 receptorprovided by RGD
Primary source
RGD:620612
See related
Ensembl:ENSRNOG00000015259
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pthr2
Summary
binds parathyroid hormone and induces cAMP accumulation [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 5.2) and Adrenal (RPKM 1.3) See more
Orthologs

Genomic context

See Pth2r in Genome Data Viewer
Location:
9q32
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (72052966..72158343)
106 current Rn_Celera (GCF_000002265.2) 9 AC_000077.1 (64101423..64205579)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (70414061..70518866, complement)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene uncharacterized LOC108351946 Neighboring gene similar to transcription factor 19 Neighboring gene cytochrome c oxidase subunit 5B, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
parathyroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
parathyroid hormone 2 receptor
Names
PTH2 receptor
parathyroid hormone receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031089.2NP_112351.1  parathyroid hormone 2 receptor precursor

    See identical proteins and their annotated locations for NP_112351.1

    Status: PROVISIONAL

    Source sequence(s)
    U55836
    UniProtKB/Swiss-Prot
    P70555
    Related
    ENSRNOP00000021099.1, ENSRNOT00000021099.2
    Conserved Domains (2) summary
    pfam00002
    Location:139406
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:63125
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    72052966..72158343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596653.1XP_017452142.1  parathyroid hormone 2 receptor isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    64101423..64205579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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