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Psen2 presenilin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81751, updated on 12-Aug-2018

Summary

Official Symbol
Psen2provided by RGD
Official Full Name
presenilin 2provided by RGD
Primary source
RGD:621060
See related
Ensembl:ENSRNOG00000002879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
mutations in human homolog responsible for chromosome 1-linked familial Alzheimer's disease; expression increased during brain development but decreased in the adult [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 62.9), Liver (RPKM 50.6) and 9 other tissues See more
Orthologs

Genomic context

See Psen2 in Genome Data Viewer
Location:
13q26
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98513600..98539347, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (103521460..103547174, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase alpha Neighboring gene coenzyme Q8A Neighboring gene uncharacterized LOC102553289 Neighboring gene uncharacterized LOC102553362

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
Notch receptor processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
 
brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
cell fate specification ISO
Inferred from Sequence Orthology
more info
 
cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
forebrain development ISO
Inferred from Sequence Orthology
more info
 
hair follicle development ISO
Inferred from Sequence Orthology
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
locomotion ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of coagulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
protein maturation ISO
Inferred from Sequence Orthology
more info
 
protein processing IEA
Inferred from Electronic Annotation
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
protein transport ISO
Inferred from Sequence Orthology
more info
 
regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
skin morphogenesis ISO
Inferred from Sequence Orthology
more info
 
somitogenesis ISO
Inferred from Sequence Orthology
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Z disc ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular_component ND
No biological Data available
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
presenilin-2
Names
PS-2
NP_112349.2
XP_006250467.1
XP_006250469.1
XP_006250470.1
XP_006250472.1
XP_008768099.1
XP_017454428.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031087.2NP_112349.2  presenilin-2

    See identical proteins and their annotated locations for NP_112349.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078805
    UniProtKB/Swiss-Prot
    O88777
    Related
    ENSRNOP00000049605.3, ENSRNOT00000040203.4
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    98513600..98539347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250408.3XP_006250470.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_006250470.1

    UniProtKB/Swiss-Prot
    O88777
    Related
    ENSRNOP00000070964.1, ENSRNOT00000091715.1
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin
  2. XM_006250405.3XP_006250467.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_006250467.1

    UniProtKB/Swiss-Prot
    O88777
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin
  3. XM_006250407.3XP_006250469.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_006250469.1

    UniProtKB/Swiss-Prot
    O88777
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin
  4. XM_017598939.1XP_017454428.1  presenilin-2 isoform X1

    UniProtKB/Swiss-Prot
    O88777
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin
  5. XM_008769877.2XP_008768099.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_008768099.1

    UniProtKB/Swiss-Prot
    O88777
    Conserved Domains (1) summary
    pfam01080
    Location:82438
    Presenilin; Presenilin
  6. XM_006250410.3XP_006250472.1  presenilin-2 isoform X2

    Conserved Domains (1) summary
    pfam01080
    Location:82437
    Presenilin; Presenilin

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    91515731..91532398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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