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Pros1 protein S [ Rattus norvegicus (Norway rat) ]

Gene ID: 81750, updated on 26-Sep-2017
Official Symbol
Pros1provided by RGD
Official Full Name
protein Sprovided by RGD
Primary source
RGD:620971
See related
Ensembl:ENSRNOG00000048723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pros
Summary
component of the Protein C/Protein S anticoagulant system; human homolog interacts with factor Xa, factor Va, and phospholipids to inhibit prothrombin activation [RGD, Feb 2006]
Orthologs
Location:
7q11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (1206648..1288140)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (1199864..1279998)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351591 Neighboring gene similar to Eif4g2 protein Neighboring gene ADP-ribosylation factor like GTPase 13B Neighboring gene syntaxin 19 Neighboring gene solute carrier family 22 (organic anion transporter), member 7, pseudogene 1 Neighboring gene nidogen-2-like

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of coagulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
blood microparticle IEA
Inferred from Electronic Annotation
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
vitamin K-dependent protein S
Names
protein S (alpha)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031086.2NP_112348.2  vitamin K-dependent protein S precursor

    See identical proteins and their annotated locations for NP_112348.2

    Status: VALIDATED

    Source sequence(s)
    BC091117, CB580854, CB790907, CK366505, CV105055, DV727991, DY571157
    UniProtKB/TrEMBL
    M0R5R0
    Related
    ENSRNOP00000064737.1, ENSRNOT00000073689.1
    Conserved Domains (6) summary
    smart00069
    Location:2385
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:119155
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00054
    Location:329459
    Laminin_G_1; Laminin G domain
    pfam07645
    Location:201241
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:168199
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl22861
    Location:514646
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    1206648..1288140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765045.2XP_008763267.1  vitamin K-dependent protein S isoform X2

    Conserved Domains (5) summary
    cd00054
    Location:232
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00054
    Location:206336
    Laminin_G_1; Laminin G domain
    pfam07645
    Location:78118
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:4576
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl22861
    Location:391523
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. XM_006240719.3XP_006240781.1  vitamin K-dependent protein S isoform X1

    Conserved Domains (5) summary
    cd00054
    Location:3975
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00054
    Location:249379
    Laminin_G_1; Laminin G domain
    pfam07645
    Location:121161
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:88119
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl22861
    Location:434566
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    237157..317730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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