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Pde2a phosphodiesterase 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 81743, updated on 18-Apr-2019

Summary

Official Symbol
Pde2aprovided by RGD
Official Full Name
phosphodiesterase 2Aprovided by RGD
Primary source
RGD:620965
See related
Ensembl:ENSRNOG00000019560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pde2; Pde2a2; CGS-PDE
Summary
activation induces decreased cAMP accumulation; involved in nitric oxide mediated signaling in cardiac fibroblasts [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 258.3), Adrenal (RPKM 218.3) and 8 other tissues See more
Orthologs

Genomic context

See Pde2a in Genome Data Viewer
Location:
1q32
Exon count:
32
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166534643..166626158)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (172724783..172816723)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene StAR-related lipid transfer domain containing 10 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene microRNA 139 Neighboring gene ADP-ribosyltransferase 2b Neighboring gene similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Potential readthrough

Included gene: Arap1

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
GAF domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
TPR domain binding IEA
Inferred from Electronic Annotation
more info
 
TPR domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP binding IEA
Inferred from Electronic Annotation
more info
 
cGMP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
PubMed 
drug binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphate ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphate ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
aorta development ISO
Inferred from Sequence Orthology
more info
PubMed 
cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
cGMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
cGMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac septum development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to 2,3,7,8-tetrachlorodibenzodioxine IEA
Inferred from Electronic Annotation
more info
 
cellular response to 2,3,7,8-tetrachlorodibenzodioxine ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to cGMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to cGMP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to macrophage colony-stimulating factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to mechanical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
coronary vasculature development ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
heart valve development ISO
Inferred from Sequence Orthology
more info
PubMed 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of vascular permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of vascular permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
response to hydrogen sulfide IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
axon ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
hippocampal mossy fiber IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cGMP-dependent 3',5'-cyclic phosphodiesterase
Names
cyclic GMP-stimulated phosphodiesterase
phosphodiesterase 2A, cGMP-stimulated
NP_001137319.1
NP_001257533.1
NP_112341.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143847.2NP_001137319.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (PDE2A3). This variant is assembled from partial rat transcripts. The full-length exon combination is based on the mouse ortholog, NM_001008548.4.
    Source sequence(s)
    AC122631, AC128828
    UniProtKB/Swiss-Prot
    Q01062
    UniProtKB/TrEMBL
    F8WFW5
    Related
    ENSRNOP00000026586.3, ENSRNOT00000026586.5
    Conserved Domains (2) summary
    smart00065
    Location:404553
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:650883
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001270604.2NP_001257533.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate exon in the 5' UTR, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (PDE2A1) that is shorter and has a distinct N-terminus, compared to isoform PDE2A3.
    Source sequence(s)
    AC122631, AC128828
    UniProtKB/TrEMBL
    A0A0G2K876
    Related
    ENSRNOP00000074500.1, ENSRNOT00000090959.1
    Conserved Domains (2) summary
    smart00065
    Location:385534
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:631864
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_031079.2NP_112341.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor

    See identical proteins and their annotated locations for NP_112341.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and has a distinct 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC122631, AC128828
    UniProtKB/Swiss-Prot
    Q01062
    Conserved Domains (2) summary
    smart00065
    Location:397546
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:643876
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    166534643..166626158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    153905701..153995649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_073045.1: Suppressed sequence

    Description
    NR_073045.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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