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Pde1c phosphodiesterase 1C [ Rattus norvegicus (Norway rat) ]

Gene ID: 81742, updated on 12-Jan-2022

Summary

Official Symbol
Pde1cprovided by RGD
Official Full Name
phosphodiesterase 1Cprovided by RGD
Primary source
RGD:68332
See related
Ensembl:ENSRNOG00000012337
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and sensory perception of smell. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 43.5), Kidney (RPKM 40.2) and 8 other tissues See more
Orthologs
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Genomic context

See Pde1c in Genome Data Viewer
Location:
4q24
Exon count:
24
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (85300858..85777948, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (86359762..86925044, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene ITPR interacting domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 17 Neighboring gene MICOS complex subunit Mic26-like Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Names
3',5'-cyclic-AMP phosphodiesterase
3',5'-cyclic-GMP phosphodiesterase
cam-PDE 1C
cyclic nucleotide phosphodiesterase 1 C
phosphodiesterase 1C calmodulin-dependent (70kD)
NP_112340.1
XP_008761144.2
XP_038964360.1
XP_038964361.1
XP_038964362.1
XP_038964363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031078.2NP_112340.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

    See identical proteins and their annotated locations for NP_112340.1

    Status: PROVISIONAL

    Source sequence(s)
    L41045
    UniProtKB/Swiss-Prot
    Q63421
    Related
    ENSRNOP00000096395.1, ENSRNOT00000098186.1
    Conserved Domains (2) summary
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    85300858..85777948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108433.1XP_038964361.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    Related
    ENSRNOP00000084095.1, ENSRNOT00000097934.1
    Conserved Domains (3) summary
    PTZ00121
    Location:603695
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  2. XM_008762922.3XP_008761144.2  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    Conserved Domains (3) summary
    PTZ00121
    Location:543635
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  3. XM_039108434.1XP_038964362.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    Related
    ENSRNOP00000017531.8, ENSRNOT00000017531.8
    Conserved Domains (3) summary
    PTZ00121
    Location:543635
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  4. XM_039108432.1XP_038964360.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:603695
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  5. XM_039108435.1XP_038964363.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

    Related
    ENSRNOP00000089783.1, ENSRNOT00000118567.1
    Conserved Domains (3) summary
    PTZ00121
    Location:603690
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RNA

  1. XR_005503320.1 RNA Sequence

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